User profiles for Mark D.M. Leiserson
Mark DM LeisersonMosaic Verified email at mosaic.us Cited by 28929 |
[HTML][HTML] Mutational landscape and significance across 12 major cancer types
The Cancer Genome Atlas (TCGA) has used the latest sequencing and analysis methods to
identify somatic variants across thousands of tumours. Here we present data and analytical …
identify somatic variants across thousands of tumours. Here we present data and analytical …
[PDF][PDF] Integrated genomic characterization of pancreatic ductal adenocarcinoma
…, G Petersen, D Klimstra, N Bardeesy, MDM Leiserson… - Cancer cell, 2017 - cell.com
We performed integrated genomic, transcriptomic, and proteomic profiling of 150 pancreatic
ductal adenocarcinoma (PDAC) specimens, including samples with characteristic low …
ductal adenocarcinoma (PDAC) specimens, including samples with characteristic low …
Pan-cancer network analysis identifies combinations of rare somatic mutations across pathways and protein complexes
Cancers exhibit extensive mutational heterogeneity, and the resulting long-tail phenomenon
complicates the discovery of genes and pathways that are significantly mutated in cancer. …
complicates the discovery of genes and pathways that are significantly mutated in cancer. …
Genetic mechanisms of immune evasion in colorectal cancer
To understand the genetic drivers of immune recognition and evasion in colorectal cancer,
we analyzed 1,211 colorectal cancer primary tumor samples, including 179 classified as …
we analyzed 1,211 colorectal cancer primary tumor samples, including 179 classified as …
[PDF][PDF] The integrated genomic landscape of thymic epithelial tumors
Thymic epithelial tumors (TETs) are one of the rarest adult malignancies. Among TETs,
thymoma is the most predominant, characterized by a unique association with autoimmune …
thymoma is the most predominant, characterized by a unique association with autoimmune …
[HTML][HTML] Integrated analysis of germline and somatic variants in ovarian cancer
…, C Lu, MD McLellan, MDM Leiserson… - Nature …, 2014 - nature.com
We report the first large-scale exome-wide analysis of the combined germline–somatic
landscape in ovarian cancer. Here we analyse germline and somatic alterations in 429 ovarian …
landscape in ovarian cancer. Here we analyse germline and somatic alterations in 429 ovarian …
[HTML][HTML] Patterns and functional implications of rare germline variants across 12 cancer types
Large-scale cancer sequencing data enable discovery of rare germline cancer susceptibility
variants. Here we systematically analyse 4,034 cases from The Cancer Genome Atlas …
variants. Here we systematically analyse 4,034 cases from The Cancer Genome Atlas …
[HTML][HTML] Simultaneous identification of multiple driver pathways in cancer
MDM Leiserson, D Blokh, R Sharan… - PLoS computational …, 2013 - journals.plos.org
Distinguishing the somatic mutations responsible for cancer (driver mutations) from random,
passenger mutations is a key challenge in cancer genomics. Driver mutations generally …
passenger mutations is a key challenge in cancer genomics. Driver mutations generally …
[HTML][HTML] CoMEt: a statistical approach to identify combinations of mutually exclusive alterations in cancer
Cancer is a heterogeneous disease with different combinations of genetic alterations
driving its development in different individuals. We introduce CoMEt, an algorithm to identify …
driving its development in different individuals. We introduce CoMEt, an algorithm to identify …
Precision oncology: the road ahead
Current efforts in precision oncology largely focus on the benefit of genomics-guided therapy.
Yet, advances in sequencing techniques provide an unprecedented view of the complex …
Yet, advances in sequencing techniques provide an unprecedented view of the complex …