Spontaneous coronary artery dissection (SCAD) has emerged as an important cause of acute
coronary syndrome, myocardial infarction, and sudden death, particularly among young …

Aortic aneurysm is common, accounting for 1–2% of all deaths in industrialized countries.
Early theories of the causes of human aneurysm mostly focused on inherited or acquired …

Transforming growth factor–β (TGFβ) signaling drives aneurysm progression in multiple
disorders, including Marfan syndrome (MFS), and therapies that inhibit this signaling cascade …

Loeys-Dietz syndrome (LDS) associates with a tissue signature for high transforming growth
factor (TGF)-β signaling but is often caused by heterozygous mutations in genes encoding …

Article-at-a-Glance Background A growing body of literature shows that when patterns of care
are widely divergent, clinical outcomes suffer and, as a result, safety may be compromised. …

Elevated transforming growth factor (TGF)-β signaling has been implicated in the pathogenesis
of syndromic presentations of aortic aneurysm, including Marfan syndrome (MFS) and …

Loeys-Dietz syndrome (LDS) is a connective tissue disorder that is characterized by a high
risk for aneurysm and dissection throughout the arterial tree and phenotypically resembles …

Thoracic aortic aneurysm is a potentially life-threatening condition in that it places patients
at risk for aortic dissection or rupture. However, our modern understanding of the …

Background : Thoracic aortic aneurysms progressively enlarge and predispose to acute
aortic dissections. Up to 25% of individuals with thoracic aortic disease harbor an underlying …

Enlargement or aneurysm of the aorta predisposes to dissection, an important cause of
sudden death. We trained a deep learning model to evaluate the dimensions of the ascending …