User profiles for Mark F. Lythgoe

Mark Lythgoe

Professor of Biomedical Imaging, University College London
Verified email at ucl.ac.uk
Cited by 15705

[HTML][HTML] Imaging biomarker roadmap for cancer studies

…, EL Leen, JS Lewis, Y Liu, MF Lythgoe… - Nature reviews Clinical …, 2017 - nature.com
Imaging biomarkers (IBs) are integral to the routine management of patients with cancer. IBs
used daily in oncology include clinical TNM stage, objective response and left ventricular …

De novo cardiomyocytes from within the activated adult heart after injury

…, D Yellon, J Riegler, AN Price, MF Lythgoe… - Nature, 2011 - nature.com
A significant bottleneck in cardiovascular regenerative medicine is the identification of a
viable source of stem/progenitor cells that could contribute new muscle after ischaemic heart …

In vivo imaging of glucose uptake and metabolism in tumors

…, E Årstad, DL Thomas, RB Pedley, MF Lythgoe… - Nature medicine, 2013 - nature.com
Tumors have a greater reliance on anaerobic glycolysis for energy production than normal
tissues. We developed a noninvasive method for imaging glucose uptake in vivo that is based …

Compartment models of the diffusion MR signal in brain white matter: a taxonomy and comparison

…, T Schneider, B Siow, MG Hall, MF Lythgoe… - Neuroimage, 2012 - Elsevier
This paper aims to identify the minimum requirements for an accurate model of the diffusion
MR signal in white matter of the brain. We construct a taxonomy of multi-compartment …

Impaired glymphatic function and clearance of tau in an Alzheimer's disease model

…, EA Nagelhus, MJ O'Neill, JA Wells, MF Lythgoe - Brain, 2020 - academic.oup.com
The glymphatic system, that is aquaporin 4 (AQP4) facilitated exchange of CSF with interstitial
fluid (ISF), may provide a clearance pathway for protein species such as amyloid-β and tau…

[HTML][HTML] Deep in vivo photoacoustic imaging of mammalian tissues using a tyrosinase-based genetic reporter

…, AR Pizzey, B Philip, T Marafioti, MF Lythgoe… - Nature …, 2015 - nature.com
Photoacoustic imaging allows absorption-based high-resolution spectroscopic in vivo imaging
at a depth beyond that of optical microscopy. Until recently, photoacoustic imaging has …

[HTML][HTML] Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma

…, IP Williams, BM Siow, MF Lythgoe… - Nature …, 2021 - nature.com
Glioblastoma multiforme (GBM) is the most common and aggressive form of primary brain
cancer, for which effective therapies are urgently needed. Chimeric antigen receptor (CAR)-…

Noninvasive quantification of solid tumor microstructure using VERDICT MRI

…, SP Johnson, V Rajkumar, RB Pedley, MF Lythgoe… - Cancer research, 2014 - AACR
There is a need for biomarkers that are useful for noninvasive imaging of tumor pathophysiology
and drug efficacy. Through its use of endogenous water, diffusion-weighted MRI (DW-…

Magnetic resonance imaging of mesenchymal stem cells homing to pulmonary metastases using biocompatible magnetic nanoparticles

…, M Turmaine, AN Price, Q Pankhurst, MF Lythgoe… - Cancer research, 2009 - AACR
The ability of mesenchymal stem cells (MSC) to specifically home to tumors has suggested
their potential use as a delivery vehicle for cancer therapeutics. MSC integration into tumors …

[HTML][HTML] A rat decellularized small bowel scaffold that preserves villus-crypt architecture for intestinal regeneration

…, MA Birchall, A Atala, S Soker, MF Lythgoe… - Biomaterials, 2012 - Elsevier
Management of intestinal failure remains a clinical challenge and total parenteral nutrition,
intestinal elongation and/or transplantation are partial solutions. In this study, using a …