User profiles for Mark F. Lythgoe
Mark LythgoeProfessor of Biomedical Imaging, University College London Verified email at ucl.ac.uk Cited by 15705 |
[HTML][HTML] Imaging biomarker roadmap for cancer studies
Imaging biomarkers (IBs) are integral to the routine management of patients with cancer. IBs
used daily in oncology include clinical TNM stage, objective response and left ventricular …
used daily in oncology include clinical TNM stage, objective response and left ventricular …
De novo cardiomyocytes from within the activated adult heart after injury
A significant bottleneck in cardiovascular regenerative medicine is the identification of a
viable source of stem/progenitor cells that could contribute new muscle after ischaemic heart …
viable source of stem/progenitor cells that could contribute new muscle after ischaemic heart …
In vivo imaging of glucose uptake and metabolism in tumors
Tumors have a greater reliance on anaerobic glycolysis for energy production than normal
tissues. We developed a noninvasive method for imaging glucose uptake in vivo that is based …
tissues. We developed a noninvasive method for imaging glucose uptake in vivo that is based …
Compartment models of the diffusion MR signal in brain white matter: a taxonomy and comparison
This paper aims to identify the minimum requirements for an accurate model of the diffusion
MR signal in white matter of the brain. We construct a taxonomy of multi-compartment …
MR signal in white matter of the brain. We construct a taxonomy of multi-compartment …
Impaired glymphatic function and clearance of tau in an Alzheimer's disease model
The glymphatic system, that is aquaporin 4 (AQP4) facilitated exchange of CSF with interstitial
fluid (ISF), may provide a clearance pathway for protein species such as amyloid-β and tau…
fluid (ISF), may provide a clearance pathway for protein species such as amyloid-β and tau…
[HTML][HTML] Deep in vivo photoacoustic imaging of mammalian tissues using a tyrosinase-based genetic reporter
…, AR Pizzey, B Philip, T Marafioti, MF Lythgoe… - Nature …, 2015 - nature.com
Photoacoustic imaging allows absorption-based high-resolution spectroscopic in vivo imaging
at a depth beyond that of optical microscopy. Until recently, photoacoustic imaging has …
at a depth beyond that of optical microscopy. Until recently, photoacoustic imaging has …
[HTML][HTML] Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma
…, IP Williams, BM Siow, MF Lythgoe… - Nature …, 2021 - nature.com
Glioblastoma multiforme (GBM) is the most common and aggressive form of primary brain
cancer, for which effective therapies are urgently needed. Chimeric antigen receptor (CAR)-…
cancer, for which effective therapies are urgently needed. Chimeric antigen receptor (CAR)-…
Noninvasive quantification of solid tumor microstructure using VERDICT MRI
…, SP Johnson, V Rajkumar, RB Pedley, MF Lythgoe… - Cancer research, 2014 - AACR
There is a need for biomarkers that are useful for noninvasive imaging of tumor pathophysiology
and drug efficacy. Through its use of endogenous water, diffusion-weighted MRI (DW-…
and drug efficacy. Through its use of endogenous water, diffusion-weighted MRI (DW-…
Magnetic resonance imaging of mesenchymal stem cells homing to pulmonary metastases using biocompatible magnetic nanoparticles
…, M Turmaine, AN Price, Q Pankhurst, MF Lythgoe… - Cancer research, 2009 - AACR
The ability of mesenchymal stem cells (MSC) to specifically home to tumors has suggested
their potential use as a delivery vehicle for cancer therapeutics. MSC integration into tumors …
their potential use as a delivery vehicle for cancer therapeutics. MSC integration into tumors …
[HTML][HTML] A rat decellularized small bowel scaffold that preserves villus-crypt architecture for intestinal regeneration
…, MA Birchall, A Atala, S Soker, MF Lythgoe… - Biomaterials, 2012 - Elsevier
Management of intestinal failure remains a clinical challenge and total parenteral nutrition,
intestinal elongation and/or transplantation are partial solutions. In this study, using a …
intestinal elongation and/or transplantation are partial solutions. In this study, using a …