In this report, we describe new HDAC inhibitors designed to exploit a unique sub-pocket in
the HDAC8 active site. These compounds were based on inspection of the available HDAC8 …

To achieve the high degree of processivity required for DNA replication, DNA polymerases
associate with ring-shaped sliding clamps that encircle the template DNA and slide freely …

Replicative polymerases (pols) cannot accommodate damaged template bases, and these
pols stall when such offenses are encountered during S phase. Rather than repairing the …

DNA repair proteins conduct a genome-wide search to detect and repair sites of DNA
damage wherever they occur. Human alkyladenine DNA glycosylase (AAG) is responsible for …

Spontaneous DNA damage occurs throughout the genome, requiring that DNA repair enzymes
search each nucleotide every cell cycle. This search is postulated to be more efficient if …

In eukaryotes, DNA polymerase δ (pol δ) is responsible for replicating the lagging strand
template and anchors to the proliferating cell nuclear antigen (PCNA) sliding clamp to form a …

During S-phase, minor DNA damage may be overcome by DNA damage tolerance (DDT)
pathways that bypass such obstacles, postponing repair of the offending damage to complete …

Timely repair of chromosomal double-strand breaks is required for genome integrity and
cellular viability. The polymerase theta-mediated end joining pathway has an important role in …

DNA replication requires the sliding clamp, a ring-shaped protein complex that encircles DNA,
where it acts as an essential cofactor for DNA polymerases and other proteins. The sliding …

During DNA replication, DNA lesions in lagging strand templates are initially encountered
by DNA polymerase δ (pol δ) holoenzymes comprised of pol δ and the PCNA processivity …