User profiles for Mark Holt

Mark Holt

King's College London
Verified email at kcl.ac.uk
Cited by 4314

Transition metal-tin chemistry

MS Holt, WL Wilson, JH Nelson - Chemical Reviews, 1989 - ACS Publications
have been reviewed, but it has been several years since the last comprehensive review. 1-4
There are a variety of synthetic methods available for the formation of transition metal-tin …

Directional migration of neural crest cells in vivo is regulated by Syndecan-4/Rac1 and non-canonical Wnt signaling/RhoA

…, C Carmona-Fontaine, S Kuriyama, J Larraín, MR Holt… - 2008 - journals.biologists.com
Directed cell migration is crucial for development, but most of our current knowledge is derived
from in vitro studies. We analyzed how neural crest (NC)cells migrate in the direction of …

Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex

B Serrels, A Serrels, VG Brunton, M Holt… - Nature cell …, 2007 - nature.com
Networks of actin filaments, controlled by the Arp2/3 complex, drive membrane protrusion
during cell migration. How integrins signal to the Arp2/3 complex is not well understood. Here, …

The focal-adhesion vasodilator-stimulated phosphoprotein (VASP) binds to the proline-rich domain in vinculin

NPJ Brindle, MR Holt, JE Davies, CJ Price… - Biochemical …, 1996 - portlandpress.com
In mammalian cells vasodilator-stimulated phosphoprotein (VASP) is localized to focal
adhesions and areas of dynamic membrane activity where it is thought to have a role in actin-…

Role of vinculin in regulating focal adhesion turnover

RM Saunders, MR Holt, L Jennings, DH Sutton… - European journal of cell …, 2006 - Elsevier
Although vinculin (−/−) mouse embryo fibroblasts assemble focal adhesions (FAs), they
spread more slowly, less extensively, and close a wound more rapidly than vinculin (+/+) cells. …

Treatment of osteitis pubis in athletes: results of corticosteroid injections

MA Holt, JS Keene, BK Graf… - The American journal of …, 1995 - journals.sagepub.com
This study presents the results of treatment of osteitis pubis in 12 intercollegiate athletes. Early
in this series, athletes were treated with prolonged rest, oral antiin flammatory medications…

The structure and regulation of human muscle α-actinin

…, C Schreiner, AA Polyansky, EA Gkougkoulia, MR Holt… - 2014 - refubium.fu-berlin.de
The spectrin superfamily of proteins plays key roles in assembling the actin cytoskeleton in
various cell types, crosslinks actin filaments, and acts as scaffolds for the assembly of large …

Interactions with titin and myomesin target obscurin and obscurin-like 1 to the M-band–implications for hereditary myopathies

A Fukuzawa, S Lange, M Holt, A Vihola… - Journal of cell …, 2008 - journals.biologists.com
Obscurin, a giant modular muscle protein implicated in G-protein and protein-kinase signalling,
can localize to both sarcomeric Z-disks and M-bands. Interaction of obscurin with the Z-…

Diminished sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) expression contributes to airway remodelling in bronchial asthma

K Mahn, SJ Hirst, S Ying, MR Holt… - Proceedings of the …, 2009 - National Acad Sciences
Phenotypic modulation of airway smooth muscle (ASM) is an important feature of airway
remodeling in asthma that is characterized by enhanced proliferation and secretion of pro-…

Rapid actin transport during cell protrusion

D Zicha, IM Dobbie, MR Holt, J Monypenny… - Science, 2003 - science.org
Transformed rat fibroblasts expressing two variants of green fluorescent protein, each fused
to β-actin, were used to study actin dynamics during cell protrusion. The recently developed …