[PDF][PDF] Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice

AA Shahmirzadi, D Edgar, CY Liao, YM Hsu, M Lucanic… - Cell metabolism, 2020 - cell.com
Metabolism and aging are tightly connected. Alpha-ketoglutarate is a key metabolite in the
tricarboxylic acid (TCA) cycle, and its levels change upon fasting, exercise, and aging. Here, …

N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans

M Lucanic, JM Held, MC Vantipalli, IM Klang… - Nature, 2011 - nature.com
Dietary restriction is a robust means of extending adult lifespan and postponing age-related
disease in many species, including yeast, nematode worms, flies and rodents 1 , 2 . Studies …

[PDF][PDF] Vitamin D promotes protein homeostasis and longevity via the stress response pathway genes skn-1, ire-1, and xbp-1

…, S Davis, TR Oron, DJ Sorensen, M Lucanic… - Cell reports, 2016 - cell.com
Vitamin D has multiple roles, including the regulation of bone and calcium homeostasis.
Deficiency of 25-hydroxyvitamin D, the major circulating form of vitamin D, is associated with an …

[HTML][HTML] Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects

M Lucanic, WT Plummer, E Chen, J Harke… - Nature …, 2017 - nature.com
Limiting the debilitating consequences of ageing is a major medical challenge of our time.
Robust pharmacological interventions that promote healthy ageing across diverse genetic …

Pharmacological lifespan extension of invertebrates

M Lucanic, GJ Lithgow, S Alavez - Ageing research reviews, 2013 - Elsevier
There is considerable interest in identifying small, drug-like compounds that slow aging in
multiple species, particularly in mammals. Such compounds may prove to be useful in treating …

[HTML][HTML] A RAC/CDC-42–Independent GIT/PIX/PAK Signaling Pathway Mediates Cell Migration in C. elegans

M Lucanic, HJ Cheng - PLoS genetics, 2008 - journals.plos.org
P21 activated kinase (PAK), PAK interacting exchange factor (PIX), and G protein coupled
receptor kinase interactor (GIT) compose a highly conserved signaling module controlling cell …

The Caenorhabditis elegans P21-activated kinases are differentially required for UNC-6/netrin-mediated commissural motor axon guidance

M Lucanic, M Kiley, N Ashcroft, N L'etoile, HJ Cheng - 2006 - journals.biologists.com
P21 activated kinases (PAKs) are major downstream effectors of rac-related small GTPases
that regulate various cellular processes. We have identified the new PAK gene max-2 in a …

[HTML][HTML] Automated lifespan determination across Caenorhabditis strains and species reveals assay-specific effects of chemical interventions

SA Banse, M Lucanic, CA Sedore, AL Coleman-Hulbert… - Geroscience, 2019 - Springer
The goal of the Caenorhabditis Intervention Testing Program is to identify robust and
reproducible pro-longevity interventions that are efficacious across genetically diverse cohorts in …

Chemical activation of a food deprivation signal extends lifespan

M Lucanic, T Garrett, I Yu, F Calahorro… - Aging …, 2016 - Wiley Online Library
Model organisms subject to dietary restriction ( DR ) generally live longer. Accompanying
this lifespan extension are improvements in overall health, based on multiple metrics. This …

[HTML][HTML] Age-related micro-RNA abundance in individual C. elegans

M Lucanic, J Graham, G Scott, D Bhaumik… - Aging (Albany …, 2013 - ncbi.nlm.nih.gov
Non-coding small RNAs of the micro-RNA class (miRNA) are conserved regulators of gene
function with a broad impact on biological processes. We screened miRNA levels for age-…