Lipid rafts are specialized structures on the plasma membrane that have an altered lipid
composition as well as links to the cytoskeleton. It has been proposed that these structures are …

Ketamine produces rapid and robust antidepressant effects in depressed patients within
hours of administration, often when traditional antidepressant compounds have failed to …

The ratio of α- to β-receptors is thought to regulate the lipolytic index of adipose depots. To
determine whether increasing the activity of the β 1 -adrenergic receptor (AR) in adipose …

To study behavior of activated Gα s in living cells, green fluorescent protein (GFP) was inserted
within the internal amino acid sequence of Gα s to generate a Gα s -GFP fusion protein. …

Background Longitudinal neuroimaging studies of major depressive disorder (MDD) have
most commonly assessed the effects of antidepressants from the serotonin reuptake inhibitor …

G proteins mediate signals from membrane G protein coupled receptors to the cell interior,
evoking significant regulation of cell physiology. The cytoskeleton contributes to cell …

Upon binding hormones or drugs, many G protein-coupled receptors are internalized,
leading to receptor recycling, receptor desensitization, and down-regulation. Much less …

… localization of Gα s in lipid rafts (Donati and Rasenick, 2005). Finally, attenuated G s /AC …
We also thank members of the Rasenick laboratory for critical review and discussion of this …

G proteins serve many functions involving the transfer of signals from cell surface receptors
to intracellular effector molecules. Considerable evidence suggests that there is an …

Recent in vivo and in vitro studies have demonstrated that Gsα migrates from a Triton X-100
(TX-100)-insoluble membrane domain (lipid raft) to a TX-100-soluble nonraft membrane …