Singlet oxygen ( 1 O 2 ) is believed to be the major cytotoxic agent involved in photodynamic
therapy (PDT). Measurement of 1 O 2 near‐infrared (NIR) luminescence at 1270 nm in …

As photodynamic therapy (PDT) continues to develop and find new clinical indications,
robust individualized dosimetry is warranted to achieve effective treatments. We posit that the …

Singlet oxygen ( 1 O 2 ) is widely believed to be the major cytotoxic agent involved in
photodynamic therapy (PDT). We showed recently that measurement of the weak near infrared …

We report a new concept for type-II photosensitization, based on incorporating the photosensitizer
(PS) and a singlet-oxygen ( 1 O 2 ) quenching/scavenging molecule onto a disease-…

Imaging of targeted fluorescent probes offers significant advantages for investigating
disease and tissue function in animal models in vivo. Conversely, macroscopic tomographic …

Fluorogenic imaging agents emitting in the near-infrared are becoming important research
tools for disease investigation in vivo. Often pathophysiological states such as cancer and …

Circulating tumor cells (CTCs) are of great interest in cancer research, but methods for their
enumeration remain far from optimal. We developed a new small animal research tool called …

The ability to visualize molecular processes and cellular regulators of complex pulmonary
diseases such as asthma, chronic obstructive pulmonary disease (COPD), or adult respiratory …

To date, singlet oxygen ( 1 O 2 ) luminescence (SOL) detection was predictive of photodynamic
therapy (PDT) treatment responses both in vitro and in vivo, but accurate quantification is …

We report a new class of photodynamic molecular beacon (PMB) with tumor specific mRNA-triggered
control of singlet oxygen ( 1 O 2 ) production. The beacon contains a single-…