User profiles for Mark R. Denison
 | Mark Denison or Denison MR or denison MR or denison MRVanderbilt University Verified email at vanderbilt.edu Cited by 29900 |
[HTML][HTML] SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness
A vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is needed to
control the coronavirus disease 2019 (COVID-19) global pandemic. Structural studies have …
control the coronavirus disease 2019 (COVID-19) global pandemic. Structural studies have …
[HTML][HTML] An mRNA vaccine against SARS-CoV-2—preliminary report
…, JD Chappell, MR Denison… - New England journal …, 2020 - Mass Medical Soc
Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged
in late 2019 and spread globally, prompting an international effort to accelerate development …
in late 2019 and spread globally, prompting an international effort to accelerate development …
[HTML][HTML] Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV
…, JY Feng, T Cihlar, R Jordan, MR Denison… - Nature …, 2020 - nature.com
Middle East respiratory syndrome coronavirus (MERS-CoV) is the causative agent of a
severe respiratory disease associated with more than 2468 human infections and over 851 …
severe respiratory disease associated with more than 2468 human infections and over 851 …
Durability of mRNA-1273 vaccine–induced antibodies against SARS-CoV-2 variants
…, ES Yang, Y Zhang, JD Chappell, MR Denison - Science, 2021 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mutations may diminish
vaccine-induced protective immune responses, particularly as antibody titers wane over time. …
vaccine-induced protective immune responses, particularly as antibody titers wane over time. …
Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses
Emerging viral infections are difficult to control because heterogeneous members periodically
cycle in and out of humans and zoonotic hosts, complicating the development of specific …
cycle in and out of humans and zoonotic hosts, complicating the development of specific …
[HTML][HTML] Safety and immunogenicity of SARS-CoV-2 mRNA-1273 vaccine in older adults
…, M Makhene, JD Chappell, MR Denison… - … England Journal of …, 2020 - Mass Medical Soc
Background Testing of vaccine candidates to prevent infection with severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) in an older population is important, since increased …
syndrome coronavirus 2 (SARS-CoV-2) in an older population is important, since increased …
[HTML][HTML] Durability of responses after SARS-CoV-2 mRNA-1273 vaccination
…, M Makhene, JD Chappell, MR Denison… - … England Journal of …, 2021 - Mass Medical Soc
Immunogenicity and the mRNA-1273 SARS-CoV-2 Vaccine Thirty-four adults received two
100-μg injections of the mRNA-1273 SARS-CoV-2 vaccine, and serum anti–spike protein …
100-μg injections of the mRNA-1273 SARS-CoV-2 vaccine, and serum anti–spike protein …
Coronavirus susceptibility to the antiviral remdesivir (GS-5734) is mediated by the viral polymerase and the proofreading exoribonuclease
…, RL Mackman, MO Clarke, RS Baric, MR Denison - MBio, 2018 - Am Soc Microbiol
Emerging coronaviruses (CoVs) cause severe disease in humans, but no approved therapeutics
are available. The CoV nsp14 exoribonuclease (ExoN) has complicated development …
are available. The CoV nsp14 exoribonuclease (ExoN) has complicated development …
An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice
Coronaviruses (CoVs) traffic frequently between species resulting in novel disease outbreaks,
most recently exemplified by the newly emerged SARS-CoV-2, the causative agent of …
most recently exemplified by the newly emerged SARS-CoV-2, the causative agent of …
Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen
…, AN Kettenbach, MR Denison… - Proceedings of the …, 2017 - National Acad Sciences
Middle East respiratory syndrome coronavirus (MERS-CoV) is a lineage C betacoronavirus
that since its emergence in 2012 has caused outbreaks in human populations with case-…
that since its emergence in 2012 has caused outbreaks in human populations with case-…