A gut-derived metabolite alters brain activity and anxiety behaviour in mice
Integration of sensory and molecular inputs from the environment shapes animal behaviour.
A major site of exposure to environmental molecules is the gastrointestinal tract, in which …
A major site of exposure to environmental molecules is the gastrointestinal tract, in which …
Golgi structure in three dimensions: functional insights from the normal rat kidney cell
MS Ladinsky, DN Mastronarde, JR McIntosh… - The Journal of cell …, 1999 - rupress.org
Three-dimensional reconstructions of portions of the Golgi complex from cryofixed, freeze-substituted
normal rat kidney cells have been made by dual-axis, high-voltage EM tomography …
normal rat kidney cells have been made by dual-axis, high-voltage EM tomography …
Gut microbiota utilize immunoglobulin A for mucosal colonization
GP Donaldson, MS Ladinsky, KB Yu, JG Sanders… - Science, 2018 - science.org
The immune system responds vigorously to microbial infection while permitting lifelong
colonization by the microbiome. Mechanisms that facilitate the establishment and stability of the …
colonization by the microbiome. Mechanisms that facilitate the establishment and stability of the …
[PDF][PDF] Microbiota imbalance induced by dietary sugar disrupts immune-mediated protection from metabolic syndrome
…, LP Araujo, T Tanoue, K Atarashi, MS Ladinsky… - Cell, 2022 - cell.com
How intestinal microbes regulate metabolic syndrome is incompletely understood. We show
that intestinal microbiota protects against development of obesity, metabolic syndrome, and …
that intestinal microbiota protects against development of obesity, metabolic syndrome, and …
Cellular origin and ultrastructure of membranes induced during poliovirus infection
A Schlegel, TH Giddings Jr, MS Ladinsky… - Journal of …, 1996 - Am Soc Microbiol
Poliovirus RNA replicative complexes are associated with cytoplasmic membranous structures
that accumulate during viral infection. These membranes were immunoisolated by using …
that accumulate during viral infection. These membranes were immunoisolated by using …
A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice
Amyloids are a class of protein with unique self-aggregation properties, and their aberrant
accumulation can lead to cellular dysfunctions associated with neurodegenerative diseases. …
accumulation can lead to cellular dysfunctions associated with neurodegenerative diseases. …
[PDF][PDF] Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy
Neutralizing antibodies (NAbs) are effective in treating COVID-19, but the mechanism of
immune protection is not fully understood. Here, we applied live bioluminescence imaging (BLI) …
immune protection is not fully understood. Here, we applied live bioluminescence imaging (BLI) …
Whole-body tissue stabilization and selective extractions via tissue-hydrogel hybrids for high-resolution intact circuit mapping and phenotyping
To facilitate fine-scale phenotyping of whole specimens, we describe here a set of tissue
fixation-embedding, detergent-clearing and staining protocols that can be used to transform …
fixation-embedding, detergent-clearing and staining protocols that can be used to transform …
Intestinal host response to SARS-CoV-2 infection and COVID-19 outcomes in patients with gastrointestinal symptoms
Background & Aims Given that gastrointestinal (GI) symptoms are a prominent extrapulmonary
manifestation of COVID-19, we investigated intestinal infection with SARS-CoV-2, its …
manifestation of COVID-19, we investigated intestinal infection with SARS-CoV-2, its …
Cisternal organization of the endoplasmic reticulum during mitosis
L Lu, MS Ladinsky, T Kirchhausen - Molecular biology of the cell, 2009 - Am Soc Cell Biol
The endoplasmic reticulum (ER) of animal cells is a single, dynamic, and continuous membrane
network of interconnected cisternae and tubules spread out throughout the cytosol in …
network of interconnected cisternae and tubules spread out throughout the cytosol in …