Integration of sensory and molecular inputs from the environment shapes animal behaviour.
A major site of exposure to environmental molecules is the gastrointestinal tract, in which …

Three-dimensional reconstructions of portions of the Golgi complex from cryofixed, freeze-substituted
normal rat kidney cells have been made by dual-axis, high-voltage EM tomography …

The immune system responds vigorously to microbial infection while permitting lifelong
colonization by the microbiome. Mechanisms that facilitate the establishment and stability of the …

How intestinal microbes regulate metabolic syndrome is incompletely understood. We show
that intestinal microbiota protects against development of obesity, metabolic syndrome, and …

Poliovirus RNA replicative complexes are associated with cytoplasmic membranous structures
that accumulate during viral infection. These membranes were immunoisolated by using …

Amyloids are a class of protein with unique self-aggregation properties, and their aberrant
accumulation can lead to cellular dysfunctions associated with neurodegenerative diseases. …

Neutralizing antibodies (NAbs) are effective in treating COVID-19, but the mechanism of
immune protection is not fully understood. Here, we applied live bioluminescence imaging (BLI) …

To facilitate fine-scale phenotyping of whole specimens, we describe here a set of tissue
fixation-embedding, detergent-clearing and staining protocols that can be used to transform …

Background & Aims Given that gastrointestinal (GI) symptoms are a prominent extrapulmonary
manifestation of COVID-19, we investigated intestinal infection with SARS-CoV-2, its …

The endoplasmic reticulum (ER) of animal cells is a single, dynamic, and continuous membrane
network of interconnected cisternae and tubules spread out throughout the cytosol in …