Aims: The protein degradation machinery plays a critical role in the maintenance of cellular
homeostasis, preventing the accumulation of damaged or misfolded proteins and controlling …

Proteasomes are large macromolecular complexes with multiple distinct catalytic activities
that are each vital to human brain health and disease. Despite their importance, standardized …

Forming long-term memories is crucial for adaptive behavior and survival in changing
environments. The molecular consolidation processes which underlie the formation of these long-…

Freely-moving rodents can solve short-term memory (STM) tasks using “response bridging”
strategies, relying on motor patterns instead of mnemonic functions. This limits the …

Group I chaperonins are a highly conserved family of essential proteins that self-assemble
into molecular nanoboxes that mediate the folding of cytoplasmic proteins in bacteria and …

Four proteasome subtypes are commonly present in mammalian tissues: standard
proteasomes, which contain the standard catalytic subunits β1, β2 and β5; immunoproteasomes …

Background: Thymic epithelial tumors (TETs), although rare, represent the most common
malignancy of the anterior mediastinum in adults. To date, there are no routinely used tumor …