The number of myonuclei within a muscle fiber is an important factor in muscle growth, but its
regulation during muscle adaptation is not well understood. We aimed to elucidate the time …

We present the time course of change in the muscle transcriptome 1 h after the last exercise
bout of a daily resistance training program lasting 2, 10, 20, or 30 days. Daily exercise in rat …

UBR5 is an E3 ubiquitin ligase positively associated with anabolism, hypertrophy, and recovery
from atrophy in skeletal muscle. The precise mechanisms underpinning UBR5’s role in …

Circadian rhythms that influence mammalian homeostasis and overall health have received
increasing interest over the past two decades. The molecular clock, which is present in …

Laminopathies are a clinically heterogeneous group of disorders caused by mutations in
the LMNA gene, which encodes the nuclear envelope proteins lamins A and C. The most …

Understanding the role of mechanical loading and exercise in skeletal muscle (SkM) is
paramount for delineating the molecular mechanisms that govern changes in muscle mass. …

Transcription factors (TFs) play a key role in regulating gene expression and responses to
stimuli. We conducted an integrated analysis of chromatin accessibility, DNA methylation, and …

Myonuclei transcriptionally regulate muscle fibers during homeostasis and adaptation to
exercise. Their subcellular location and quantity are important when characterizing phenotypes …

Time-of-day differences in acute exercise performance in mice are well established with late
active phase (afternoon) runners exhibiting significantly greater endurance performance …

This thesis will present an introduction to cellular and molecular adaptation to loading and
unloading of skeletal muscle, whilst exploring the advantages and disadvantages of current …