Objective: Several studies have suggested an increased frequency of variants in the gene
encoding angiogenin (ANG) in patients with amyotrophic lateral sclerosis (ALS). Interestingly, …

… Gijselinck I, Van Langenhove T, van der Zee J, et al. A C9orf72 promoter repeat
expansion in a Flanders-Belgian cohort with disorders of the frontotemporal lobar …

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are devastating
neurodegenerative disorders with clinical, genetic, and neuropathological overlap. …

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are devastating
neurodegenerative disorders with clinical, genetic, and neuropathological overlap. A …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder with a substantial
heritable component. In pedigrees affected by its familial form, incomplete penetrance is …

Increasing evidence suggests that defective RNA processing contributes to the development
of amyotrophic lateral sclerosis (ALS). This may be especially true for ALS caused by a …

Frontotemporal lobar degeneration with TAR DNA-binding protein 43 inclusions (FTLD-TDP)
is the most common pathology associated with frontotemporal dementia (FTD). Repeat …

Background Hexanucleotide repeat expansions in chromosome 9 open reading frame 72 (C9ORF72)
are the most common known genetic cause of frontotemporal dementia (FTD) and …

Identifying large expansions of short tandem repeats (STRs), such as those that cause
amyotrophic lateral sclerosis (ALS) and fragile X syndrome, is challenging for short-read whole-…

To identify genetic factors contributing to amyotrophic lateral sclerosis (ALS), we conducted
whole-exome analyses of 1,022 index familial ALS (FALS) cases and 7,315 controls. In a …