As a key component of the standard of care for glioblastoma, radiotherapy induces several
immune resistance mechanisms, such as upregulation of CD47 and PD-L1. Here, leveraging …

Background Malignant glioma is the most common and lethal primary brain tumour, with
dismal survival rates and no effective treatment. We examined the safety and activity of NSC-…

Autotaxin (ATX) is a secreted lysophospholipase D that catalyzes the production of
lysophosphatidic acid (LPA), a pleiotropic growth‐factor–like lysophospholipid. Increased ATX …

Tumor-associated myeloid cells (TAMCs) are key drivers of immunosuppression in the
tumor microenvironment, which profoundly impedes the clinical response to immune-dependent …

Triple‐negative breast cancer (TNBC) is the most aggressive subtype of breast cancer,
characterized by an aberrant metabolic phenotype with high metastatic capacity, resulting in poor …

Purpose: Diffuse intrinsic pontine glioma (DIPG) is among the deadliest of pediatric brain
tumors. Radiotherapy is the standard-of-care treatment for DIPG, but offers only transient relief …

Methods RNA-seq, RT-qPCR, and flow cytometry were used to determine IL15Rα expression
in paired peripheral and tumor-infiltrating immune cells of GBM patients and two syngeneic …

Background: Interleukin 13 receptor alpha 2 subunit (IL13Rα2) is overexpressed in
glioblastoma (GBM), metastatic colorectal cancer (CRC) and ovarian cancer (OC). Here, we …

… Markella Zannikou … Markella Zannikou … Fenton, Markella Zannikou, Liliana Ilut,
Mariafausta Fischietti, Chunni Ji, Chidera V. Oku, Curt M. Horvath, I. …

Idiopathic pulmonary fibrosis (IPF) is characterized by exuberant deposition of extracellular
matrix components, leading to the deterioration of lung architecture and respiratory functions. …