Integrin-containing focal adhesions transmit extracellular signals across the plasma
membrane to modulate cell adhesion, signalling and survival. Although integrins are known to …

Epithelial–mesenchymal transition (EMT) in cells is a developmental process adopted during
tumorigenesis that promotes metastatic capacity. In this study, we advance understanding …

Tissue homeostasis is dependent on the controlled localization of specific cell types and the
correct composition of the extracellular stroma. While the role of the cancer stroma in tumour …

Cell-type-specific functions and identity are tightly regulated by interactions between the cell
cytoskeleton and the extracellular matrix (ECM). Human pluripotent stem cells (hPSCs) …

A modern day light microscope has evolved from a tool devoted to making primarily empirical
observations to what is now a sophisticated , quantitative device that is an integral part of …

While it is clear that key transcriptional programmes are important for maintaining pluripotency,
the requirement for cell adhesion to the extracellular matrix remains poorly defined. …

We studied the effects of xylitol on biofilms containing xylitol-resistant (Xr) and xylitol-sensitive
(Xs) Streptococcus mutans, Actinomyces naeslundii and S. sanguinis. The biofilms were …

SHARPIN is a widely expressed multifunctional protein implicated in cancer, inflammation,
linear ubiquitination and integrin activity inhibition; however, its contribution to epithelial …

Cells are highly dynamic and adopt variable shapes and sizes. These variations are
biologically important but challenging to investigate in a spatiotemporally controlled manner. …

Recently, we demonstrated that integrin adhesion to the extracellular matrix at the cleavage
furrow is essential for cytokinesis of adherent cells. Here, we report that tight junction protein …