Computationally estimated apolipoproteins B and A1 in predicting cardiovascular risk

…, V Salomaa, ML Hannuksela, MJ Savolainen… - Atherosclerosis, 2013 - Elsevier
OBJECTIVE: Apolipoproteins B (apoB) and A1 (apoA1) may be better markers of atherosclerosis
than serum lipids. We used computational methods to estimate apoB and apoA1 from …

Genome-wide association study identifies multiple loci influencing human serum metabolite levels

…, K Silander, DM Dick, RJ Rose, MJ Savolainen… - Nature …, 2012 - nature.com
Nuclear magnetic resonance assays allow for measurement of a wide range of metabolic
phenotypes. We report here the results of a GWAS on 8,330 Finnish individuals genotyped and …

[HTML][HTML] Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA

…, M Perola, S Blankenberg, MJ Savolainen… - Nature …, 2016 - nature.com
Genome-wide association studies have identified numerous loci linked with complex diseases,
for which the molecular mechanisms remain largely unclear. Comprehensive molecular …

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

…, I Prokopenko, R Puls, A Ruokonen, MJ Savolainen… - Nature …, 2011 - nature.com
Concentrations of liver enzymes in plasma are widely used as indicators of liver disease.
We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci …

High-throughput serum NMR metabonomics for cost-effective holistic studies on systemic metabolism

…, T Lehtimäki, J Viikari, OT Raitakari, MJ Savolainen… - Analyst, 2009 - pubs.rsc.org
A high-throughput proton (1H) nuclear magnetic resonance (NMR) metabonomics approach
is introduced to characterise systemic metabolic phenotypes. The methodology combines …

3 years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomised, double-blind trial

…, S Madsbad, A Rissanen, S Nieminen, M Savolainen… - The Lancet, 2017 - thelancet.com
Background Liraglutide 3·0 mg was shown to reduce bodyweight and improve glucose
metabolism after the 56-week period of this trial, one of four trials in the SCALE programme. In …

Metabolic signatures of insulin resistance in 7,098 young adults

…, T Tukiainen, J Kettunen, MJ Savolainen… - Diabetes, 2012 - Am Diabetes Assoc
Metabolite associations with insulin resistance were studied in 7,098 young Finns (age 31 ±
3 years; 52% women) to elucidate underlying metabolic pathways. Insulin resistance was …

Effects of an isocaloric healthy N ordic diet on insulin sensitivity, lipid profile and inflammation markers in metabolic syndrome–a randomized study (SYSDIET)

…, K Hermansen, MJ Savolainen… - Journal of internal …, 2013 - Wiley Online Library
Background Different healthy food patterns may modify cardiometabolic risk. We investigated
the effects of an isocaloric healthy N ordic diet on insulin sensitivity, lipid profile, blood …

[HTML][HTML] Metabolic signatures of adiposity in young adults: Mendelian randomization analysis and effects of weight change

…, M Kaakinen, JS Viikari, MJ Savolainen… - PLoS …, 2014 - journals.plos.org
Background Increased adiposity is linked with higher risk for cardiometabolic diseases. We
aimed to determine to what extent elevated body mass index (BMI) within the normal weight …

Metabonomic, transcriptomic, and genomic variation of a population cohort

…, AJ Kangas, S Männistö, MJ Savolainen… - Molecular systems …, 2010 - embopress.org
Comprehensive characterization of human tissues promises novel insights into the biological
architecture of human diseases and traits. We assessed metabonomic, transcriptomic, and …