[HTML][HTML] RNAi-based small molecule repositioning reveals clinically approved urea-based kinase inhibitors as broadly active antivirals

M Lesch, M Luckner, M Meyer, F Weege… - PLoS …, 2019 - journals.plos.org
Influenza viruses (IVs) tend to rapidly develop resistance to virus-directed vaccines and
common antivirals targeting pathogen determinants, but novel host-directed approaches might …

[HTML][HTML] Quantitative proteomic approach identifies Vpr binding protein as novel host factor supporting influenza A virus infections in human cells

…, B Bogdanow, S Saenger, M Budt, M Lesch… - Molecular & Cellular …, 2017 - ASBMB
Influenza A virus (IAV) infections are a major cause for respiratory disease in humans, which
affects all age groups and contributes substantially to global morbidity and mortality. IAV …

[HTML][HTML] Genetic characterization of an adapted pandemic 2009 H1N1 influenza virus that reveals improved replication rates in human lung epithelial cells

X Wörmann, M Lesch, RW Welke, K Okonechnikov… - Virology, 2016 - Elsevier
The 2009 influenza pandemic originated from a swine-origin H1N1 virus, which, although less
pathogenic than anticipated, may acquire additional virulence-associated mutations in the …

Relevance of host cell surface glycan structure for cell specificity of influenza A virus

…, D Zhang, J Liu, A Geissner, A Sadewasser, M Lesch… - bioRxiv, 2017 - biorxiv.org
Influenza A viruses (IAV) initiate infection via binding of the viral hemagglutinin (HA) to
sialylated glycan receptors on host cells. HAs receptor specificity towards sialic acid (SA) is well …

[HTML][HTML] Relevance of Host Cell Surface Glycan Structure for Cell Specificity of Influenza A Viruses

…, R Zhu, Q Huang, A Geissner, A Sadewasser, M Lesch… - Viruses, 2023 - mdpi.com
Influenza A viruses (IAVs) initiate infection via binding of the viral hemagglutinin (HA) to
sialylated glycans on host cells. HA’s receptor specificity towards individual glycans is well …

Effectiveness of evidence-based asthma interventions

…, A Markus, M Gerstein, DM Stevens, JK Lesch… - …, 2017 - publications.aap.org
METHODS: Children (aged 5–12 years; N= 590) with moderate to severe asthma were enrolled
from 3 intervention and 3 geographically/capacity-matched control sites in high-risk, low-…

Traces on algebras of parameter dependent pseudodifferential operators and the eta–invariant

M Lesch, M Pflaum - Transactions of the American Mathematical Society, 2000 - ams.org
We identify Melrose’s suspended algebra of pseudodifferential operators with a subalgebra
of the algebra of parametric pseudodifferential operators with parameter space $\mathbb {R} …

[BOOK][B] Connes–Chern character for manifolds with boundary and eta cochains

M Lesch, H Moscovici, M Pflaum - 2012 - ams.org
We express the Connes-Chern of the Dirac operator associated to a b-metric on a manifold
with boundary in terms of a retracted cocycle in relative cyclic cohomology, whose …

Cannabinoid receptor 1 blocker rimonabant (SR 141716) for treatment of alcohol dependence: results from a placebo-controlled, double-blind trial

M Soyka, G Koller, P Schmidt, OM Lesch… - Journal of clinical …, 2008 - journals.lww.com
Multiple lines of evidence suggest that the endocannabinoid system is implicated in the
development of alcohol dependence. In addition, in animal models, the cannabinoid receptor 1 …

Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder

…, H Beckmann, L Bellodi, KP Lesch - Human molecular …, 1999 - academic.oup.com
A genetic contribution to the pathogenesis of panic disorder has been demonstrated by clinical
genetic studies. Molecular genetic studies have focused on candidate genes suggested …