Childhood acute lymphoblastic leukemia (ALL) can often be traced to a pre-leukemic clone
carrying a prenatal genetic lesion. Postnatally acquired mutations then drive clonal evolution …

Here a new, intrinsically pluripotent, CD45-negative population from human cord blood,
termed unrestricted somatic stem cells (USSCs) is described. This rare population grows …

B cells are selected for an intermediate level of B-cell antigen receptor (BCR) signalling
strength: attenuation below minimum (for example, non-functional BCR) 1 or hyperactivation …

Interferon-induced transmembrane protein 3 (IFITM3) has previously been identified as an
endosomal protein that blocks viral infection 1 , 2 – 3 . Here we studied clinical cohorts of …

Tyrosine kinase inhibitors (TKIs) are widely used to treat patients with leukaemia driven by
BCR–ABL1 (ref. 1 ) and other oncogenic tyrosine kinases 2 , 3 . Recent efforts have focused …

B-lymphoid transcription factors, such as PAX5 and IKZF1, are critical for early B-cell development
1 , 2 , yet lesions of the genes encoding these transcription factors occur in over 80% …

Fat mass and obesity-associated protein (FTO), an RNA N 6 -methyladenosine (m 6 A)
demethylase, plays oncogenic roles in various cancers, presenting an opportunity for the …

B-cell leukemia/lymphoma 2 (BCL-2) prevents commitment to programmed cell death at the
mitochondrion. It remains a challenge to identify those tumors that are best treated by …

DNA and histone modifications have notable effects on gene expression 1 . Being the most
prevalent internal modification in mRNA, the N 6 -methyladenosine (m 6 A) mRNA …

Hypoxia in tumors is generally associated with chemoresistance and radioresistance. However,
the correlation between the heterodimeric hypoxia‐inducible factor‐1 (HIF‐1) and the …