The metabolome, the collection of small-molecule chemical entities involved in metabolism,
has traditionally been studied with the aim of identifying biomarkers in the diagnosis and …

Background Three pregnancies with male offspring in one family were complicated by severe
polyhydramnios and prematurity. One fetus died; the other two had transient massive salt-…

Vasopressin’s action in renal cells to regulate water transport depends on protein phosphorylation.
Here we used mass spectrometry–based quantitative phosphoproteomics to identify …

Mammalian kidneys constantly filter large amounts of liquid, with almost complete retention
of albumin and other macromolecules in the plasma. Breakdown of the three-layered renal …

Primary cilia are sensory, antennae‐like organelles present on the surface of many cell types.
They have been involved in a variety of diseases collectively termed ciliopathies. As cilia …

Current therapies for Fabry disease are based on reversing intracellular accumulation of
globotriaosylceramide (Gb3) by enzyme replacement therapy (ERT) or chaperone-mediated …

We used a systems biology-based approach to investigate the basis of cell-specific expression
of the water channel aquaporin-2 (AQP2) in the renal collecting duct. Computational …

Quantitative mass spectrometry was used to identify hormone-dependent signaling pathways
in renal medullary thick ascending limb (mTAL) cells via phosphoproteomic analysis. …

Damage to and loss of glomerular podocytes has been identified as the culprit lesion in
progressive kidney diseases. Here, we combine mass spectrometry-based proteomics with …

Background Primary membranous nephropathy (MN) is caused by circulating autoantibodies
binding to antigens on the podocyte surface. PLA 2 R1 is the main target antigen in 70%–…