Most plant microRNAs (miRNAs) have perfect or near-perfect complementarity with their
targets. This is consistent with their primary mode of action being cleavage of target mRNAs, …

Plant microRNAs (miRNAs) affect only a small number of targets with high sequence
complementarity, while animal miRNAs usually have hundreds of targets with limited …

We identified genetic mutations in CD19 and loss of heterozygosity at the time of CD19 –
relapse to chimeric antigen receptor (CAR) therapy. The mutations are present in the vast …

To understand the relationships between the non-GCIMP glioblastoma (GBM) subgroups, we
performed mathematical modeling to predict the temporal sequence of driver events during …

The identification of JAK2/MPL mutations in patients with myeloproliferative neoplasms (MPN)
has led to the clinical development of JAK kinase inhibitors, including ruxolitinib. …

Purpose: We aimed to validate and improve prognostic signatures for high-risk urothelial
carcinoma of the bladder. Experimental Design: We evaluated microarray data from 93 patients …

Background Ovarian cancer causes more than 15000 deaths per year in the United States.
The survival of patients is quite heterogeneous, and accurate prognostic tools would help …

Despite the increasing interest in targeting stromal elements of the tumor microenvironment,
we still face tremendous challenges in developing adequate therapeutics to modify the …

This article introduces a manually curated data collection for gene expression meta-analysis
of patients with ovarian cancer and software for reproducible preparation of similar …

Human tumors result from an evolutionary process operating on somatic cells within tissues,
whereby natural selection operates on the phenotypic variability generated by the …