Coronavirus disease 2019 (COVID-19) can damage cerebral small vessels and cause
neurological symptoms. Here we describe structural changes in cerebral small vessels of patients …

This is not a book about how to run a company. It is about how to look at the world differently.
Ultimately, this will help the reader to deal with complexity more effectively. The market …

According to the neurovascular hypothesis, impairment of low-density lipoprotein receptor–related
protein-1 (LRP1) in brain capillaries of the blood-brain barrier (BBB) contributes to …

Activation of the transcription factor nuclear factor-κB (NF-κB) has been suggested to participate
in chronic disorders, such as diabetes and its complications. In contrast to the short and …

Little is known about the mechanisms converting psychosocial stress into cellular dysfunction.
Various genes, up-regulated in atherosclerosis but also by psychosocial stress, are …

The transcription factor NF-κB is a regulator of cell death or survival. To investigate the role
of NF-κB in neuronal cell death, we studied its activation in a rodent model of stroke. In the …

This study establishes a mechanism for metabolic hyperalgesia based on the glycolytic
metabolite methylglyoxal. We found that concentrations of plasma methylglyoxal above 600 nM …

Background and Purpose—Pretreatment with intraventricular brain-derived neurotrophic
factor (BDNF) reduces ischemic damage after focal cerebral ischemia. In this experiment we …

In ischemic stroke, the necrotic core is surrounded by a zone of inflammation, in which
delayed cell death aggravates the initial insult. Here, we provide evidence that the receptor for …

Background and Purpose— Several studies have shown, in different populations, that
modest elevation of plasma C-reactive protein (CRP) in the range seen in apparently healthy …