User profiles for Markus W. Löffler

Markus W. Löffler

Physician-Scientist (MD), University of Tübingen (Germany), Depts. of Immunology/ General …
Verified email at med.uni-tuebingen.de
Cited by 7097

[HTML][HTML] Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

…, HMA Kaafarani, H Lederhuber, MW Löffler… - The Lancet, 2020 - thelancet.com
Background The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
on postoperative recovery needs to be understood to inform clinical decision making during …

Timing of surgery following SARS‐CoV‐2 infection: an international prospective cohort study

…, M Albertsmeier, H Lederhuber, MW Löffler… - …, 2021 - Wiley Online Library
Peri‐operative SARS‐CoV‐2 infection increases postoperative mortality. The aim of this
study was to determine the optimal duration of planned delay before surgery in patients who …

[HTML][HTML] A COVID-19 peptide vaccine for the induction of SARS-CoV-2 T cell immunity

…, S Hörber, A Peter, C Meisner, I Fischer, MW Löffler… - Nature, 2022 - nature.com
T cell immunity is central for the control of viral infections. CoVac-1 is a peptide-based vaccine
candidate, composed of SARS-CoV-2 T cell epitopes derived from various viral proteins 1 …

[HTML][HTML] Towards new horizons: characterization, classification and implications of the tumour antigenic repertoire

SP Haen, MW Löffler, HG Rammensee… - Nature Reviews Clinical …, 2020 - nature.com
Immune-checkpoint inhibition provides an unmatched level of durable clinical efficacy in
various malignancies. Such therapies promote the activation of antigen-specific T cells, …

[HTML][HTML] Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis

…, T Knorpp, N Schneiderhan-Marra, MW Löffler… - Nature …, 2020 - nature.com
Psoriasis is an inflammatory skin disease with strong neutrophil (PMN) infiltration and high
levels of the antimicrobial peptide, LL37. LL37 in complex with DNA and RNA is thought to …

Elective surgery cancellations due to the COVID‐19 pandemic: global predictive modelling to inform surgical recovery plans

…, H Lederhuber, S Leventoglu, MW Löffler… - British journal of …, 2020 - Wiley Online Library
Background The COVID‐19 pandemic has disrupted routine hospital services globally. This
study estimated the total number of adult elective operations that would be cancelled …

The immunopeptidomic landscape of ovarian carcinomas

…, L Backert, T Bilich, B Ney, MW Löffler… - Proceedings of the …, 2017 - National Acad Sciences
Immunotherapies, particularly checkpoint inhibitors, have set off a revolution in cancer
therapy by releasing the power of the immune system. However, only little is known about the …

[HTML][HTML] HLA Ligand Atlas: a benign reference of HLA-presented peptides to improve T-cell-based cancer immunotherapy

…, L Regli, M Silginer, M Weller, MW Löffler… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background The human leucocyte antigen (HLA) complex controls adaptive immunity by
presenting defined fractions of the intracellular and extracellular protein content to immune cells…

[HTML][HTML] Multi-omics discovery of exome-derived neoantigens in hepatocellular carcinoma

MW Löffler, C Mohr, L Bichmann, LK Freudenmann… - Genome medicine, 2019 - Springer
Background Although mutated HLA ligands are considered ideal cancer-specific immunotherapy
targets, evidence for their presentation is lacking in hepatocellular carcinomas (HCCs). …

Outcomes from elective colorectal cancer surgery during the SARS‐CoV‐2 pandemic

…, A Litvin, A Loehrer, MW Löffler… - Colorectal …, 2021 - Wiley Online Library
Aim This study aimed to describe the change in surgical practice and the impact of SARS‐CoV‐2
on mortality after surgical resection of colorectal cancer during the initial phases of the …