Hematopoietic stem cells (HSCs) mediate regeneration of the hematopoietic system following
injury, such as following infection or inflammation. These challenges impair HSC function, …

The genetic modification of stem cells (SCs) is typically achieved using integrating vectors,
whose potential integrative genotoxicity and propensity for epigenetic silencing during …

Hematopoietic stem cells (HSCs) are canonically defined by their capacity to maintain the
HSC pool via self-renewal divisions. However, accumulating evidence suggests that HSC …

Hematopoietic stem cells (HSCs) derive from an endothelial precursor during embryonic
development and undergo endothelial to hematopoietic transition (EHT). EHT is a highly …

We have used serial single cell transplantations and mathematical modelling to interrogate
the functional potency of individual HSCs and their paired progeny, and assess cell-intrinsic …

We interrogated the functional potency of individual HSCs and their paired progeny using
serial single cell transplantations and mathematical modeling. Primary transplants consisted of …

Endothelial to hematopoietic transition (EHT) is a crucial step in the formation of definitive
hematopoietic stem cells during embryonic development. Holding such a critical …

While tumor necrosis factor (TNF)-α has key roles in appropriate pathogen and wound healing
processes, its misregulation associates with cancer, autoimmunity, bone marrow failure …

Human genetic variants are classified on the basis of potential pathogenicity to guide clinical
decisions. However, mechanistic uncertainties often preclude definitive categorization. …