Neuroanatomically precise, genome-wide maps of transcript distributions are critical resources
to complement genomic sequence data and to correlate functional and genetic brain …

Rare coding variation has historically provided the most direct connections between gene
function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 …

High-throughput cDNA microarray technology allows for the simultaneous analysis of gene
expression levels for thousands of genes and as such, rapid, relatively simple methods are …

A cardinal symptom of major depressive disorder (MDD) is the disruption of circadian patterns.
However, to date, there is no direct evidence of circadian clock dysregulation in the brains …

Background Most studies investigating the neurobiology of depression and suicide have
focused on the serotonergic system. While it seems clear that serotonergic alterations play a …

Recent findings of mitochondrial abnormalities in brains from subjects with neurological
disorders have led to a renewed search for mitochondrial abnormalities in psychiatric disorders. …

There are major concerns that specific agonal conditions, including coma and hypoxia, might
affect ribonucleic acid (RNA) integrity in postmortem brain studies. We report that agonal …

Microarray studies can be used to examine expression levels for large numbers of genes
simultaneously and may be applied to identify genes involved in schizophrenia. A microarray …

Importance Genome-wide investigations provide systematic information regarding the
neurobiology of psychiatric disorders. Objective To identify biological pathways that contribute to …

Studies of gene expression abnormalities in psychiatric or neurological disorders often
involve the use of postmortem brain tissue. Compared with single-cell organisms or clonal cell …