Complement is an essential component of innate immunity. Its activation results in the
assembly of unstable protease complexes, denominated C3/C5 convertases, leading to …

In oval-shaped Streptococcus pneumoniae, septal and longitudinal peptidoglycan syntheses
are performed by independent functional complexes: the divisome and the elongasome. …

Highlights • Recent results on the structural biology of PG hydrolases reviewed. • Structural
features of PG recognition and regulation in amidases and LTs analysed. • Shared glycan …

SPOR domains are widely present in bacterial proteins that recognize cell-wall peptidoglycan
strands stripped of the peptide stems. This type of peptidoglycan is enriched in the septal …

Antimicrobial resistance is one of the most serious health threats. Cell-wall remodeling
processes are tightly regulated to warrant bacterial survival and in some cases are directly linked …

Streptococcus pneumoniae is a leading killer of infants and immunocompromised adults and
has become increasingly resistant to major antibiotics. Therefore, the development of new …

The human pathogen Streptococcus pneumoniae is decorated with a special class of
surface-proteins known as choline-binding proteins (CBPs) attached to phosphorylcholine (PCho) …

The capsular polysaccharide (CPS) is the major virulence factor of the emerging zoonotic
pathogen Streptococcus suis. CPS differences are also the basis for serological differentiation …

Activation of C3, deposition of C3b on the target surface, and subsequent amplification by
formation of a C3-cleaving enzyme (C3-convertase; C3bBb) triggers the effector functions of …

The genome-organizing protein p6 of Bacillus subtilis bacteriophage φ29 plays an essential
role in viral development by activating the initiation of DNA replication and participating in …