Antimicrobial peptides: an alternative for innovative medicines?

JP Da Costa, M Cova, R Ferreira, R Vitorino - Applied microbiology and …, 2015 - Springer
Antimicrobial peptides are small molecules with activity against bacteria, yeasts, fungi, viruses,
bacteria, and even tumor cells that make these molecules attractive as therapeutic agents…

How apicomplexa parasites secrete and build their invasion machinery

MM Cova, MH Lamarque… - Annual Review of …, 2022 - annualreviews.org
Apicomplexa are obligatory intracellular parasites that sense and actively invade host cells.
Invasion is a conserved process that relies on the timely and spatially controlled exocytosis …

An Alveolata secretory machinery adapted to parasite host cell invasion

E Aquilini, MM Cova, SK Mageswaran… - Nature …, 2021 - nature.com
Apicomplexa are unicellular eukaryotes and obligate intracellular parasites, including
Plasmodium (the causative agent of malaria) and Toxoplasma (one of the most widespread …

Rhoptry secretion system structure and priming in Plasmodium falciparum revealed using in situ cryo-electron tomography

M Martinez, WD Chen, MM Cova, P Molnár… - Nature …, 2022 - nature.com
Apicomplexan parasites secrete contents of the rhoptries, club-shaped organelles in the
apical region, into host cells to permit their invasion and establishment of infection. The rhoptry …

[HTML][HTML] Sugar activation and glycosylation in Plasmodium

M Cova, JA Rodrigues, TK Smith, L Izquierdo - Malaria Journal, 2015 - Springer
Glycoconjugates are important mediators of host-pathogen interactions and are usually very
abundant in the surface of many protozoan parasites. However, in the particular case of …

Cross‐species comparison of mammalian saliva using an LC–MALDI based proteomic approach

P de Sousa‐Pereira, M Cova, J Abrantes… - …, 2015 - Wiley Online Library
Despite the importance of saliva in the regulation of oral cavity homeostasis, few studies have
been conducted to quantitatively compare the saliva of different mammal species. Aiming …

[HTML][HTML] Altered protein phosphorylation as a resource for potential AD biomarkers

AG Henriques, T Müller, JM Oliveira, M Cova… - Scientific reports, 2016 - nature.com
The amyloidogenic peptide, Aβ, provokes a series of events affecting distinct cellular
pathways regulated by protein phosphorylation. Aβ inhibits protein phosphatases in a dose-…

Postimplantation syndrome after endovascular aortic repair using the Anaconda™ endograft

…, MT Occhiuto, S Stegher, G Malacrida, M Cova… - Annals of Vascular …, 2014 - Elsevier
Background We report our retrospective experience on postimplantation syndrome (PIS) after
the use of Anaconda ™ endograft in patients undergoing elective endovascular repair of …

[HTML][HTML] Open fenestration for complicated acute aortic B dissection

…, S Segreti, V Grassi, C Lomazzi, M Cova… - Annals of …, 2014 - ncbi.nlm.nih.gov
Acute type B aortic dissection (ABAD) is a serious cardiovascular emergency in which morbidity
and mortality are often related to the presence of complications at clinical presentation. …

[HTML][HTML] Reduced placental transfer of antibodies against a wide range of microbial and vaccine antigens in HIV-infected women in Mozambique

…, M Ruperez, P Cistero, L Fuente-Soro, M Cova… - Frontiers in …, 2021 - frontiersin.org
Transplacental transfer of antibodies is essential for conferring protection in newborns against
infectious diseases. We assessed the impact of different factors, including gestational age …