Monoclonal antibody (mAb) drugs that stimulate antitumor immunity are transforming cancer
treatment but require optimization for maximum clinical impact. Here, we show that, unlike …

Langerhans cells (LCs) reside in the epidermis as a dense network of immune system
sentinels. These cells determine the appropriate adaptive immune response (inflammation or …

Allergen-specific responses in atopic dermatitis (AD) are skewed toward a Th2 profile.
However, individuals with AD have been shown to make effective virus-specific Th1 responses, …

BACKGROUND Matrix metalloproteinases (MMPs) are key regulators of tissue destruction
in tuberculosis (TB) and may be targets for host-directed therapy. We conducted a phase II …

Purpose: Cutaneous squamous cell carcinoma (cSCC) is the most common human cancer
with metastatic potential. Despite T cells accumulating around cSCCs, these tumors continue …

Human cutaneous dendritic cells (DCs) from epidermal and dermal compartments exhibit
functional differences in their induction of CD4+ T-cell and humoral immune responses; …

Regulation of cutaneous immunity is severely compromised in inflammatory skin disease.
To investigate the molecular crosstalk underpinning tolerance versus inflammation in atopic …

Tuberculosis (TB) is a persistent global pandemic, and standard treatment for it has not
changed for 30 years. Mycobacterium tuberculosis (Mtb) has undergone prolonged coevolution …

Langerhans cells (LCs) are professional antigen-presenting cells (APCs) residing in the
epidermis. Despite their high potential to activate T lymphocytes, current understanding of …

Mycobacterium tuberculosis (Mtb) causes the human disease tuberculosis (TB) and remains
the top global infectious pandemic after coronavirus disease 2019 (COVID-19). Furthermore…