The psychosis associated with schizophrenia is characterized by alterations in sensory
processing and perception 1 , 2 . Some antipsychotic drugs were identified by their high affinity …

Most evidence indicates that, as for family CG protein–coupled receptors (GPCRs), family A
GPCRs form homo- and heteromers. Homodimers seem to be a predominant species, with …

Molecular dynamics (MD) simulations have become an important tool for characterizing
mechanisms underlying complex processes, interpreting experimental measurements, and …

G‐protein‐coupled receptors are generally thought to be organized as dimers; whether they
form higher order oligomers is a topic of much controversy. We combined bioluminescence/…

Atypical antipsychotic drugs, such as clozapine and risperidone, have a high affinity for the
serotonin 5-HT 2A G protein-coupled receptor (GPCR), the 2AR, which signals via a G q …

G protein-coupled receptors (GPCRs) have long been considered to be monomeric
membrane proteins. Although numerous recent studies have indicated that GPCRs can form …

Functional crosstalk between G protein-coupled receptors in a homo- or heterodimeric
assembly likely involves conformational changes at the dimer interface, but the nature of this …

Mu-opioid receptor agonists represent mainstays of pain management. However, the therapeutic
use of these agents is associated with serious side effects, including potentially lethal …

The recent availability in the literature of new crystal structures of inactive G-protein coupled
receptors (GPCRs) prompted us to study the extent to which these crystal structures …

G protein-coupled receptors play a pivotal role in many physiological signaling pathways.
Mounting evidence suggests that G protein-coupled receptors, including opioid receptors, form …