User profiles for Marta Martinez-Vicente
Marta Martinez-VicenteNeurodegenerative Diseases Group. Vall d'Hebron Research Institute (VHIR), Barcelona … Verified email at vhir.org Cited by 23667 |
Autophagy maintains stemness by preventing senescence
L García-Prat, M Martínez-Vicente, E Perdiguero… - Nature, 2016 - nature.com
During ageing, muscle stem-cell regenerative function declines. At advanced geriatric age,
this decline is maximal owing to transition from a normal quiescence into an irreversible …
this decline is maximal owing to transition from a normal quiescence into an irreversible …
Fighting neurodegeneration with rapamycin: mechanistic insights
J Bové, M Martínez-Vicente, M Vila - Nature Reviews Neuroscience, 2011 - nature.com
A growing number of studies point to rapamycin as a pharmacological compound that is able
to provide neuroprotection in several experimental models of neurodegenerative diseases, …
to provide neuroprotection in several experimental models of neurodegenerative diseases, …
[HTML][HTML] Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations
…, CM Peterhoff, DM Wolfe, M Martinez-Vicente… - Cell, 2010 - cell.com
Macroautophagy is a lysosomal degradative pathway essential for neuron survival. Here, we
show that macroautophagy requires the Alzheimer's disease (AD)-related protein presenilin…
show that macroautophagy requires the Alzheimer's disease (AD)-related protein presenilin…
Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease
M Martinez-Vicente, Z Talloczy, E Wong, G Tang… - Nature …, 2010 - nature.com
Continuous turnover of intracellular components by autophagy is necessary to preserve cellular
homeostasis in all tissues. Alterations in macroautophagy, the main process responsible …
homeostasis in all tissues. Alterations in macroautophagy, the main process responsible …
[HTML][HTML] Dopamine-modified α-synuclein blocks chaperone-mediated autophagy
M Martinez-Vicente, Z Talloczy… - The Journal of …, 2008 - Am Soc Clin Investig
Altered degradation of α-synuclein (α-syn) has been implicated in the pathogenesis of
Parkinson disease (PD). We have shown that α-syn can be degraded via chaperone-mediated …
Parkinson disease (PD). We have shown that α-syn can be degraded via chaperone-mediated …
Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing
Y Wang, M Martinez-Vicente, U Krüger… - Human molecular …, 2009 - academic.oup.com
Aggregation and cleavage are two hallmarks of Tau pathology in Alzheimer disease (AD),
and abnormal fragmentation of Tau is thought to contribute to the nucleation of Tau paired …
and abnormal fragmentation of Tau is thought to contribute to the nucleation of Tau paired …
Autophagy and neurodegeneration: when the cleaning crew goes on strike
M Martinez-Vicente, AM Cuervo - The Lancet Neurology, 2007 - thelancet.com
Intracellular accumulation of altered and misfolded proteins is the basis of most
neurodegenerative disorders. Altered proteins are usually organised in the form of toxic multimeric …
neurodegenerative disorders. Altered proteins are usually organised in the form of toxic multimeric …
Lysosomal impairment in Parkinson's disease
Impairment of autophagy‐lysosomal pathways (ALPs) is increasingly regarded as a major
pathogenic event in neurodegenerative diseases, including Parkinson's disease (PD). ALP …
pathogenic event in neurodegenerative diseases, including Parkinson's disease (PD). ALP …
Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration
…, A Ramirez, M Martinez-Vicente… - Proceedings of the …, 2012 - National Acad Sciences
Parkinson disease (PD) is a progressive neurodegenerative disorder pathologically characterized
by the loss of dopaminergic neurons from the substantia nigra pars compacta and the …
by the loss of dopaminergic neurons from the substantia nigra pars compacta and the …
Protein degradation and aging
M Martinez-Vicente, G Sovak, AM Cuervo - Experimental gerontology, 2005 - Elsevier
Continuous turnover of intracellular proteins is essential for the maintenance of cellular
homeostasis and for the regulation of multiple cellular functions. The first reports showing a …
homeostasis and for the regulation of multiple cellular functions. The first reports showing a …