The autoimmune regulator (AIRE) gene is crucial for establishing central immunological
tolerance and preventing autoimmunity. Mutations in AIRE cause a rare autosomal-recessive …

Objective. Elevated levels of IL-17A have been detected in the inflamed synovium of RA
patients, and murine arthritis models deficient in IL17A have shown reduced inflammation. Our …

Longitudinal Follow-up of Autoimmune Polyendocrine Syndrome Type 1 | The Journal of
Clinical Endocrinology & Metabolism | Oxford Academic Skip to Main Content Advertisement …

Background Acquired myasthenia gravis (MG) is a rare antibody-mediated autoimmune
disease caused by impaired neuromuscular transmission, leading to abnormal muscle …

Peroxiredoxins (Prx) are thiol-dependent antioxidants containing one (1-cysteine [-Cys]) or
two (2-Cys) conserved Cys residues that protect lipids, enzymes, and DNA against reactive …

Hepatic T‐cell infiltrates and a strong genetic human leukocyte antigen association represent
characteristic features of various immune‐mediated liver diseases. Conceptually the …

We fine mapped the leukocyte antigen (HLA) region in 13,770 Parkinson’s disease (PD)
patients, 20,214 proxy-cases, and 490,861 controls of European origin. Four HLA types were …

OBJECTIVE Circumstantial evidence links 25-hydroxy vitamin D [25(OH)D], vitamin D–binding
protein (DBP), vitamin D–associated genes, and type 1 diabetes (T1D), but no studies …

Objective Recently, a functional PTPN22 variant (R263Q; rs33996649) was found to be
associated with systemic lupus erythematosus (SLE). This study was undertaken to analyze the …

The C1858T single nucleotide polymorphism in PTPN22, which is the gene encoding lymphoid
tyrosine phosphatase (LYP), confers increased risk for various autoimmune disorders in …