The concept of burnout remains enigmatic since it is only determined by behavioral characteristics.
Moreover, the differential diagnosis with depression and chronic fatigue syndrome is …

The genetic architecture of common traits, including the number, frequency, and effect sizes
of inherited variants that contribute to individual risk, has been long debated. Genome-wide …

The vast majority of genome-wide association study (GWAS) risk loci fall in non-coding regions
of the genome. One possible hypothesis is that these GWAS risk loci alter the individual's …

Type 2 diabetes affects over 300 million people, causing severe complications and premature
death, yet the underlying molecular mechanisms are largely unknown. Pancreatic islet …

Insulin resistance is a key mediator of obesity-related cardiometabolic disease, yet the
mechanisms underlying this link remain obscure. Using an integrative genomic approach, we …

A significant portion of the genome is transcribed as long noncoding RNAs (lncRNAs), several
of which are known to control gene expression. The repertoire and regulation of lncRNAs …

Several lines of evidence suggest that genome-wide association studies (GWASs) have the
potential to explain more of the "missing heritability" of common complex phenotypes. …

The intersection of genome-wide association analyses with physiological and functional
data indicates that variants regulating islet gene transcription influence type 2 diabetes (T2D) …

We apply integrative approaches to expression quantitative loci (eQTLs) from 44 tissues from
the Genotype-Tissue Expression project and genome-wide association study data. About …

We performed fine mapping of 39 established type 2 diabetes (T2D) loci in 27,206 cases and
57,574 controls of European ancestry. We identified 49 distinct association signals at these …