This study evaluates the prognostic significance of genetic abnormalities (detected at or
shortly after presentation), clinical stage, lymphocyte morphology, CD38 expression, and …

The ubiquitin-proteasome system is a major regulatory pathway of protein degradation and
plays an important role in cellular division. Fbxw7 (or hCdc4), a member of the F-box family …

SARS-CoV-2 enters host cells through an interaction between the spike glycoprotein and
the angiotensin converting enzyme 2 (ACE2) receptor. Directly preventing this interaction …

PTEN is a tumor-suppressor gene that has been shown to be under the regulatory control of
a PTEN pseudogene expressed noncoding RNA, PTENpg1. Here, we characterize a …

Broadly neutralizing antibodies (bnAbs) can protect against HIV infection but have not been
induced by human vaccination. A key barrier to bnAb induction is vaccine priming of rare …

Changes in genomic DNA methylation are recognized as important events in normal and
pathological cellular processes, contributing both to normal development and differentiation as …

Antisense transcription is a widespread phenomenon in the mammalian genome. It is
thought to play a role in regulation of gene expression, but its exact functional significance is …

Comprehensive knowledge of immunoglobulin genetics is required to advance our understanding
of B cell biology. Validated immunoglobulin variable (V) gene databases are close to …

Notch signaling is of crucial importance in normal T-cell development and Notch 1 is
frequently mutated in T-cell acute lymphoblastic leukemias (T-ALL), leading to aberrantly high …

Previous studies have indicated the presence of a putative tumor suppressor gene on
chromosome 13q14, commonly deleted in patients with B-cell chronic lymphocytic leukemia (B-…