Emerging technologies allow the high-throughput profiling of metabolic status from a blood
specimen (metabolomics). We investigated whether metabolite profiles could predict the …

Background Extreme obesity is recognized to be a risk factor for heart failure. It is unclear
whether overweight and lesser degrees of obesity also pose a risk. Methods We investigated …

Background Information is limited regarding the risk of cardiovascular disease in persons
with high-normal blood pressure (systolic pressure of 130 to 139 mm Hg, diastolic pressure of …

Background—Current definitions of hypertension are based on levels of systolic blood pressure
(SBP) and diastolic blood pressure (DBP), but not on pulse pressure (PP). We examined …

Background We attempted to characterize age-related changes in blood pressure in both
normotensive and untreated hypertensive subjects in a population-based cohort from the …

Background— Various measures of arterial stiffness and wave reflection have been
proposed as cardiovascular risk markers. Prior studies have not assessed relations of a …

Background Heart failure is a major public health problem. Long-term trends in the incidence
of heart failure and survival after its onset in the community have not been characterized. …

Background— Atrial fibrillation (AF) is the most common cardiac dysrhythmia and a source
of considerable morbidity and mortality, but lifetime risk for AF has not been estimated. …

Objective. —To study the relative and population-attributable risks of hypertension for the
development of congestive heart failure (CHF), to assess the time course of progression from …

Background— Atrial fibrillation (AF) and congestive heart failure (CHF) frequently occur
together, but there is limited information regarding their temporal relations and the combined …