[HTML][HTML] Comparison of methods and resources for cell-cell communication inference from single-cell RNA-Seq data

D Dimitrov, D Türei, M Garrido-Rodriguez… - Nature …, 2022 - nature.com
The growing availability of single-cell data, especially transcriptomics, has sparked an
increased interest in the inference of cell-cell communication. Many computational tools were …

[HTML][HTML] Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1

L Casares, V García, M Garrido-Rodríguez, E Millán… - Redox Biology, 2020 - Elsevier
Cannabidiol (CBD) is a major non-psychotropic phytocannabinoid that attracted a great
attention for its therapeutic potential against different pathologies including skin diseases. …

Integrating knowledge and omics to decipher mechanisms via large‐scale models of signaling networks

M GarridoRodriguez, K Zirngibl, O Ivanova… - Molecular systems …, 2022 - embopress.org
Signal transduction governs cellular behavior, and its dysregulation often leads to human
disease. To understand this process, we can use network models based on prior knowledge, …

[HTML][HTML] FBXW7 tumor suppressor regulation by dualspecificity tyrosine-regulated kinase 2

…, A Correa-Sáez, M Garrido-Rodríguez… - Cell Death & …, 2023 - nature.com
FBXW7 is a member of the F-box protein family, which functions as the substrate recognition
component of the SCF E3 ubiquitin ligase. FBXW7 is a main tumor suppressor due to its …

[HTML][HTML] A novel CDC25A/DYRK2 regulatory switch modulates cell cycle and survival

…, R Jiménez-Izquierdo, M Garrido-Rodríguez… - Cell Death & …, 2022 - nature.com
The cell division cycle 25A (CDC25A) phosphatase is a key regulator of cell cycle progression
that acts on the phosphorylation status of Cyclin–Cyclin-dependent kinase complexes, …

[HTML][HTML] Updating dual-specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2): molecular basis, functions and role in diseases

…, R Jiménez-Izquierdo, M Garrido-Rodríguez… - Cellular and Molecular …, 2020 - Springer
Members of the dual-specificity tyrosine-regulated kinase (DYRKs) subfamily possess a
distinctive capacity to phosphorylate tyrosine, serine, and threonine residues. Among the DYRK …

Metabolomic profiling of human lung tumor tissues–nucleotide metabolism as a candidate for therapeutic interventions and biomarkers

…, C Jiménez‐Jiménez, M GarridoRodríguez… - Molecular …, 2018 - Wiley Online Library
Although metabolomics has attracted considerable attention in the field of lung cancer (LC)
detection and management, only a very limited number of works have applied it to tissues. As …

Cannabinoid derivatives acting as dual PPARγ/CB2 agonists as therapeutic agents for systemic sclerosis

A García-Martín, M Garrido-Rodríguez… - Biochemical …, 2019 - Elsevier
The endocannabinoid system (ECS) may play a role in the pathophysiology of systemic
sclerosis (SSc). Cannabinoids acting as dual PPARγ/CB 2 agonists, such as VCE-004.8 and …

Tetrahydrocannabinolic acid A (THCA-A) reduces adiposity and prevents metabolic disease caused by diet-induced obesity

B Palomares, F Ruiz-Pino, M Garrido-Rodriguez… - Biochemical …, 2020 - Elsevier
Medicinal cannabis has remarkable therapeutic potential, but its clinical use is limited by the
psychotropic activity of Δ9-tetrahydrocannabinol (Δ9-THC). However, the biological profile …

[HTML][HTML] Effects of EHP-101 on inflammation and remyelination in murine models of Multiple sclerosis

…, A García-Martin, M Garrido-Rodríguez… - Neurobiology of …, 2020 - Elsevier
Multiple Sclerosis (MS) is characterized by a combination of inflammatory and neurodegenerative
processes in the spinal cord and the brain. Natural and synthetic cannabinoids such …