Autophagy is a conserved catabolic homeostasis process central for cellular and organismal
health. During autophagy, small single-membrane phagophores rapidly expand into large …

INTRODUCTION Macroautophagy (hereafter autophagy) is an evolutionarily conserved
lysosomal degradation pathway. It ensures cellular homeostasis and health by removing …

Autophagy is a conserved degradative process that is crucial for cellular homeostasis and
cellular quality control via the selective removal of subcellular structures such as mitochondria…

Autophagy is a central homeostasis and stress response pathway conserved in all eukaryotes.
One hallmark of autophagy is the de novo formation of autophagosomes. These double-…

To uncover the selective forces shaping life-history trait evolution across species, we
investigate the genomic basis underlying adaptations to seasonal habitat desiccation in African …

Lipid droplets (LDs) are conserved organelles for intracellular neutral lipid storage. Recent
studies suggest that LDs function as direct lipid sources for autophagy, a central catabolic …

Autophagy is a highly conserved catabolic pathway critical for stress responses and the
maintenance of cellular homeostasis. Defective autophagy contributes to the etiology of an …

To elucidate the functional roles of mitochondrial dynamics in vivo, we identified genes that
become essential in cells lacking the dynamin-related proteins Fzo1 and Dnm1, which are …

During autophagy, rapid membrane assembly expands small phagophores into large
double-membrane autophagosomes. Theoretical modeling predicts that the majority of …

Mitochondria contain tens to thousands of copies of their own genome (mitochondrial DNA [mtDNA]),
creating genetic redundancy capable of buffering mutations in mitochondrial genes …