PIWI-interacting RNAs (piRNAs) and their associated PIWI clade Argonaute proteins constitute
the core of the piRNA pathway. In gonadal cells, this conserved pathway is crucial for …

10.7554/eLife.47999.001 The PIWI-interacting RNA (piRNA) pathway is a small RNA-based
immune system that controls the expression of transposons and maintains genome integrity …

The PIWI-interacting RNA (piRNA) pathway controls transposon expression in animal germ
cells, thereby ensuring genome stability over generations. In Drosophila, piRNAs are …

… of Fabry disease.It is markedly elevated in both classic male and symptomatic female
Fabry-… Individuals with Fabry disease present clinically with a spectrum of disease severity that …

… The dermatologists Johannes Fabry and William Anderson first described ‘angiokeratoma …
One might speculate that having the Fabry trait presents a selective advantage such as …

… Increased urinary sediment Gb 3 measured in 24 h collection was thought to be useful in
diagnosing Fabry disease, particularly in females who almost always have elevated levels (…

… Fabry disease, an inherited deficiency of the lysosomal … 58 patients who had classic Fabry
disease and completed a 20-… Fabry disease is an X-linked lysosomal storage disorder that is …

Fabry disease is a rare X-linked lysosomal storage disorder due to mutations in the GLA
gene causing complete or partial deficiency of the enzyme a-galactosidase A (a-Gal A), and …

… men with nonclassical Fabry disease or … Fabry disease had a history of more events than
men with nonclassical disease or women with either phenotype; women with classical Fabry …

Homozygous HbC gene results only in mild hemolytic anemia. In HbSC disease red cells
contain equal levels of HbS and HbC. It is a paradox that HbSC exhibit a moderately severe …