Biological systems are controlled by protein complexes that associate into dynamic protein
interaction networks. We describe a strategy that analyzes protein complexes through the …

African Trypanosomes have developed elaborate mechanisms to escape the adaptive immune
response, but little is known about complement evasion particularly at the early stage of …

Bacterial nanotubes are membranous structures that have been reported to function as
conduits between cells to exchange DNA, proteins, and nutrients. Here, we investigate the …

Human histone deacetylase 6 (HDAC6) is the major deacetylase responsible for removing
the acetyl group from Lys40 of α-tubulin (αK40), which is located lumenally in polymerized …

The protein sequences found in nature represent a tiny fraction of the potential sequences
that could be constructed from the 20-amino-acid alphabet. To help define the properties that …

Wheat belongs to six major food allergens inducing IgE‐mediated hypersensitivity reaction
manifesting as cutaneous, gastrointestinal, and respiratory symptoms. Although cereals are a …

It has been more than 50 years since the discovery of dinucleoside polyphosphates (Np n
Ns) and yet their roles and mechanisms of action remain unclear. Here, we show that both …

Francisella tularensis live vaccine strain infection of mice has been established as an
experimental model of tularemia that is suitable for studies of immune mechanisms against the …

Although Ddi1-like proteins are conserved among eukaryotes, their biological functions
remain poorly characterized. Yeast Ddi1 has been implicated in cell cycle regulation, DNA-…

Linear or branched 1,3‐diketone‐linked thymidine 5′‐O‐mono‐ and triphosphate were
synthesized through CuAAC click reaction of diketone‐alkynes with 5‐azidomethyl‐dUMP or ‐…