Recent advances in functionalizations of helicene backbone
Helicenes, chiral members of the family of polyaromatic hydrocarbons, have been increasingly
used in a variety of applications in recent years. Despite their intriguing properties, wider …
used in a variety of applications in recent years. Despite their intriguing properties, wider …
Characterization of spray dried chitosan–TPP microparticles formed by two-and three-fluid nozzles
O Kašpar, M Jakubec, F Štěpánek - Powder technology, 2013 - Elsevier
Chitosan microparticles cross-linked by tri-polyphosphate (TPP) anions have been prepared
by spray drying. Two different cross-linking methods have been employed — ex-situ cross-…
by spray drying. Two different cross-linking methods have been employed — ex-situ cross-…
Cholesterol‐containing lipid nanodiscs promote an α‐synuclein binding mode that accelerates oligomerization
Dysregulation of the biosynthesis of cholesterol and other lipids has been implicated in
many neurological diseases, including Parkinson's disease. Misfolding of α‐synuclein (α‐Syn), …
many neurological diseases, including Parkinson's disease. Misfolding of α‐synuclein (α‐Syn), …
Photochemical Oxidation Specific to Distorted Aromatic Amines Providing ortho-Diketones
M Jakubec, S Hansen-Troĝyen, I Císařová… - Organic …, 2020 - ACS Publications
A straightforward visible-light-promoted oxidation of aminohelicenes providing helical ortho-diketones
is described. It is shown that the oxidation of amines proceeds via [2 + 2]-…
is described. It is shown that the oxidation of amines proceeds via [2 + 2]-…
[HTML][HTML] Plasma-derived exosome-like vesicles are enriched in lyso-phospholipids and pass the blood-brain barrier
M Jakubec, J Maple-Grĝdem, S Akbari, S Nesse… - Plos one, 2020 - journals.plos.org
Exosomes are vesicles involved in intercellular communication. Their membrane structure
and core content is largely dependent on the cell of origin. Exosomes have been investigated …
and core content is largely dependent on the cell of origin. Exosomes have been investigated …
2-Bromo [6] helicene as a key intermediate for [6] helicene functionalization
M Jakubec, T Beránek, P Jakubík… - The Journal of …, 2018 - ACS Publications
The synthesis of 2-bromo[6]helicene was revised and improved up to 51% yield. Its
reactivity was thoroughly investigated, and a library of 17 different carbon, boron, nitrogen, …
reactivity was thoroughly investigated, and a library of 17 different carbon, boron, nitrogen, …
[HTML][HTML] Goldilocks Dilemma: LPS Works Both as the Initial Target and a Barrier for the Antimicrobial Action of Cationic AMPs on E. coli
Antimicrobial peptides (AMPs) are generally membrane-active compounds that physically
disrupt bacterial membranes. Despite extensive research, the precise mode of action of AMPs …
disrupt bacterial membranes. Despite extensive research, the precise mode of action of AMPs …
Synthesis of Aza[n]helicenes (n = 4–7) via Photocyclodehydrochlorination of 1-Chloro-N-aryl-2-naphthamides
A series of aza[n]helicenes (n = 4–7) was synthesized using a photocyclodehydrochlorination
of 1-chloro-N-aryl-2-naphthamides as a general synthetic procedure introducing the …
of 1-chloro-N-aryl-2-naphthamides as a general synthetic procedure introducing the …
[HTML][HTML] IL-17-driven induction of Paneth cell antimicrobial functions protects the host from microbiota dysbiosis and inflammation in the ileum
…, J Březina, M Dobešová, A Aidarova, M Jakubec… - Mucosal …, 2023 - Elsevier
Interleukin (IL)-17 protects epithelial barriers by inducing the secretion of antimicrobial peptides.
However, the effect of IL-17 on Paneth cells (PCs), the major producers of antimicrobial …
However, the effect of IL-17 on Paneth cells (PCs), the major producers of antimicrobial …
[HTML][HTML] The effect of prebiotics on adherence of probiotics
R Kadlec, M Jakubec - Journal of dairy science, 2014 - Elsevier
Prebiotics are generally considered to promote the function or viability of probiotics via their
fermentation, but their effect on the adherence of probiotics is still unclear. In this study, we …
fermentation, but their effect on the adherence of probiotics is still unclear. In this study, we …