Immune checkpoint inhibitors, which unleash a patient’s own T cells to kill tumors, are
revolutionizing cancer treatment. To unravel the genomic determinants of response to this therapy, …

Euclid is a space-based survey mission from the European Space Agency designed to
understand the origin of the Universe's accelerating expansion. It will use cosmological probes to …

Eukaryotic cells replicate by a complex series of evolutionarily conserved events that are
tightly regulated at defined stages of the cell division cycle. Progression through this cycle …

Cancer therapy is challenged by the diversity of molecular implementations of oncogenic
processes and by the resulting variation in therapeutic responses. Projects such as The …

Transfection of small RNAs (such as small interfering RNAs (siRNAs) and microRNAs (miRNAs))
into cells typically lowers expression of many genes. Unexpectedly, increased …

10.7554/eLife.10769.001 Mutations, deletions, and changes in copy number of mitochondrial
DNA (mtDNA), are observed throughout cancers. Here, we survey mtDNA copy number …

We present an exceptional case of a patient with high-grade serous ovarian cancer, treated
with multiple chemotherapy regimens, who exhibited regression of some metastatic lesions …

To the Editor: The generation of large-scale phosphoproteomics data sets to elucidate the
phosphorylation events associated with a given phenotype or disease condition has become …

Although clonal neo-antigen burden is associated with improved response to immune
therapy, the functional basis for this remains unclear. Here we study this question in a novel …

Cancer is a leading cause of death worldwide and, despite new targeted therapies and
immunotherapies, many patients with advanced-stage- or high-risk cancers still die, owing to …