Controlled protein assembly provides a means to regulate function. Supramolecular building
blocks, including rigid macrocycles, are versatile triggers of protein assembly. Now it is …

Complex formation between cationic cytochrome c and the water‐soluble, poly‐anionic p‐phosphonatocalix[6]arene
(pclx 6 ) was investigated. A crystal structure (at 1.8 Å resolution) …

Synthetic macrocycles such as calixarenes and cucurbiturils are increasingly applied as
mediators of protein assembly and crystallization. The macrocycle can facilitate assembly by …

Here, we provide the first structural characterization of host–guest complexation between
cucurbit[7]uril (Q7) and dimethyllysine (KMe 2 ) in a model protein. Binding was dominated by …

Fanconi anemia (FA) is a rare genetic disorder caused by mutations in any of the currently
22 known FA genes. The products of these genes, along with other FA‐associated proteins, …

Protein crystals with their precise, periodic array of functional building blocks have potential
applications in biomaterials, sensing, and catalysis. This paper describes how a highly …

Protein crystallization remains a serious bottleneck to structure determination by X-ray
diffraction methods. Compounds acting as “molecular glue” provide a promising strategy to …

Di‐monoubiquitination of the FANCI‐FANCD2 (ID2) complex is a central and crucial step for
the repair of DNA interstrand crosslinks via the Fanconi anaemia pathway. While FANCD2 …

The interactions of two mono‐functionalized sulfonatocalix[4]arenes with cytochrome c were
investigated by structural and thermodynamic methods. The replacement of a single …

Ubiquitin-specific protease 1 (USP1) acts together with the cofactor UAF1 during DNA
repair processes to specifically remove monoubiquitin signals. One substrate of the USP1−UAF1 …