User profiles for Martin Pirkl
Martin PirklResearcher, University Hospital of Cologne Verified email at uk-koeln.de Cited by 219 |
[PDF][PDF] Genome-scale CRISPR screening in human intestinal organoids identifies drivers of TGF-β resistance
Forward genetic screens with genome-wide CRISPR libraries are powerful tools for resolving
cellular circuits and signaling pathways. Applying this technology to organoids, however, …
cellular circuits and signaling pathways. Applying this technology to organoids, however, …
Hierarchy of TGFβ/SMAD, Hippo/YAP/TAZ, and Wnt/β-catenin signaling in melanoma phenotype switching
F Lüönd, M Pirkl, M Hisano… - Life science …, 2022 - life-science-alliance.org
In melanoma, a switch from a proliferative melanocytic to an invasive mesenchymal phenotype
is based on dramatic transcriptional reprogramming which involves complex interactions …
is based on dramatic transcriptional reprogramming which involves complex interactions …
[HTML][HTML] Impaired humoral immunity to BQ. 1.1 in convalescent and vaccinated patients
F Dewald, M Pirkl, M Paluschinski, J Kühn… - Nature …, 2023 - nature.com
Determining SARS-CoV-2 immunity is critical to assess COVID-19 risk and the need for
prevention and mitigation strategies. We measured SARS-CoV-2 Spike/Nucleocapsid …
prevention and mitigation strategies. We measured SARS-CoV-2 Spike/Nucleocapsid …
Within-patient genetic diversity of SARS-CoV-2
SARS-CoV-2, the virus responsible for the current COVID-19 pandemic, is evolving into
different genetic variants by accumulating mutations as it spreads globally. In addition to this …
different genetic variants by accumulating mutations as it spreads globally. In addition to this …
Analysis of mutational history of multidrug‐resistant genotypes with a mutagenetic tree model
M Pirkl, J Büch, C Devaux, M Böhm… - Journal of Medical …, 2023 - Wiley Online Library
… Martin Pirkl and Joachim Büch processed the data. Martin Pirkl conducted the statistical
analysis under supervision of Thomas Lengauer. Martin Pirkl, Rolf Kaiser, and Thomas …
analysis under supervision of Thomas Lengauer. Martin Pirkl, Rolf Kaiser, and Thomas …
SARS-CoV-2 Test-to-Stay in Daycare
…, I Suárez, GH Rubio Quintanares, M Pirkl… - …, 2024 - publications.aap.org
BACKGROUND AND OBJECTIVES: Test-to-stay concepts apply serial testing of children in
daycare after exposure to SARS-CoV-2 without use of quarantine. This study aims to assess …
daycare after exposure to SARS-CoV-2 without use of quarantine. This study aims to assess …
Analyzing synergistic and non-synergistic interactions in signalling pathways using Boolean Nested Effect Models
Motivation: Understanding the structure and interplay of cellular signalling pathways is one
of the great challenges in molecular biology. Boolean Networks can infer signalling networks …
of the great challenges in molecular biology. Boolean Networks can infer signalling networks …
Viral load dynamics in SARS-CoV-2 Omicron breakthrough infections
F Dewald, S Detmer, M Pirkl, M Hellmich… - The Journal of …, 2022 - academic.oup.com
To determine viral dynamics in Omicron breakthrough infections, we measured severe acute
respiratory syndrome coronavirus 2 RNA in 206 double-vaccinated or boostered individuals…
respiratory syndrome coronavirus 2 RNA in 206 double-vaccinated or boostered individuals…
[HTML][HTML] dCas9-mediated dysregulation of gene expression in human induced pluripotent stem cells during primitive streak differentiation
V Haellman, M Pirkl, A Akmammedov, P Saxena… - Metabolic …, 2022 - Elsevier
CRISPR-based systems have fundamentally transformed our ability to study and manipulate
stem cells. We explored the possibility of using catalytically dead Cas9 (dCas9) from S. …
stem cells. We explored the possibility of using catalytically dead Cas9 (dCas9) from S. …
Multifunction 35-ghz fmcw radar with frequency scanning antenna for synthetic vision applications
FJ Tospann, M Pirkl, W Gruener - Synthetic Vision for Vehicle …, 1995 - spiedigitallibrary.org
This paper presents an experimental radar at 35 GHz in development at Daimler-Benz
Aerospace, Ulm, Airborne Systems Division. This radar uses FMCW Frequency modulation …
Aerospace, Ulm, Airborne Systems Division. This radar uses FMCW Frequency modulation …