PARP1 regulates the repair of DNA single-strand breaks generated directly, or during base
excision repair (BER). However, the role of PARP2 in these and other repair mechanisms is …

Recognition and repair of damaged replication forks are essential to maintain genome
stability and are coordinated by the combined action of the Fanconi anemia and homologous …

Components of the Fanconi anemia and homologous recombination pathways play a vital
role in protecting newly replicated DNA from uncontrolled nucleolytic degradation, …

To ensure efficient genome duplication, cells have evolved numerous factors that promote
unperturbed DNA replication and protect, repair and restart damaged forks. Here we identify …

Embryonic development is dictated by tight regulation of DNA replication, cell division and
differentiation. Mutations in DNA repair and replication genes disrupt this equilibrium, giving …

DNA lesions encountered by replicative polymerases threaten genome stability and cell cycle
progression. Here we report the identification of mutations in TRAIP, encoding an E3 RING …

Chronic infections by the hepatotropic viruses hepatitis B virus (HBV) and hepatitis C virus (HCV)
are major risk factors for the development of hepatocellular carcinoma (HCC). It is …

Chronic hepatitis C virus (HCV) infection is associated with altered lipid metabolism and
hepatocellular steatosis. Virus-induced steatosis is a cytopathic effect of HCV replication. The …

The 53BP1-RIF1-shieldin pathway maintains genome stability by suppressing nucleolytic
degradation of DNA ends at double-strand breaks (DSBs). Although RIF1 interacts with …

Defects in histone methyltransferases (HMTs) are major contributing factors in neurodevelopmental
disorders (NDDs). Heterozygous variants of SETD1A involved in histone H3 lysine 4 …