Genome-wide analysis of mammalian promoter architecture and evolution
…, K Shimokawa, J Ponjavic, CAM Semple, MS Taylor… - Nature …, 2006 - nature.com
Mammalian promoters can be separated into two classes, conserved TATA box–enriched
promoters, which initiate at a well-defined site, and more plastic, broad and evolvable CpG-…
promoters, which initiate at a well-defined site, and more plastic, broad and evolvable CpG-…
Disruption of two novel genes by a translocation co-segregating with schizophrenia
…, S Anderson, S Christie, MS Taylor… - Human molecular …, 2000 - academic.oup.com
A balanced (1;11)(q42.1;q14.3) translocation segregates with schizophrenia and related
psychiatric disorders in a large Scottish family (maximum LOD = 6.0). We hypothesize that the …
psychiatric disorders in a large Scottish family (maximum LOD = 6.0). We hypothesize that the …
Genome-wide genetic association of complex traits in heterogeneous stock mice
Difficulties in fine-mapping quantitative trait loci (QTLs) are a major impediment to progress
in the molecular dissection of complex traits in mice. Here we show that genome-wide high-…
in the molecular dissection of complex traits in mice. Here we show that genome-wide high-…
[HTML][HTML] Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development
The presence of ribonucleotides in genomic DNA is undesirable given their increased
susceptibility to hydrolysis. Ribonuclease (RNase) H enzymes that recognize and process such …
susceptibility to hydrolysis. Ribonuclease (RNase) H enzymes that recognize and process such …
Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages
Evolutionary change in gene expression is generally considered to be a major driver of
phenotypic differences between species. We investigated innate immune diversification by …
phenotypic differences between species. We investigated innate immune diversification by …
In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis
…, YK Park, X Liang, G Eng, MS Taylor… - Nature …, 2017 - nature.com
In vivo interrogation of the function of genes implicated in tumorigenesis is limited by the
need to generate and cross germline mutant mice. Here we describe approaches to model …
need to generate and cross germline mutant mice. Here we describe approaches to model …
[HTML][HTML] Long interspersed element-1 protein expression is a hallmark of many human cancers
Cancers comprise a heterogeneous group of human diseases. Unifying characteristics
include unchecked abilities of tumor cells to proliferate and spread anatomically, and the …
include unchecked abilities of tumor cells to proliferate and spread anatomically, and the …
Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor
Ghrelin is a gastric peptide hormone that stimulates weight gain in vertebrates. The
biological activities of ghrelin require octanoylation of the peptide on Ser 3 , an unusual …
biological activities of ghrelin require octanoylation of the peptide on Ser 3 , an unusual …
CEP152 is a genome maintenance protein disrupted in Seckel syndrome
Functional impairment of DNA damage response pathways leads to increased genomic
instability. Here we describe the centrosomal protein CEP152 as a new regulator of genomic …
instability. Here we describe the centrosomal protein CEP152 as a new regulator of genomic …
Generation of a selective small molecule inhibitor of the CBP/p300 bromodomain for leukemia therapy
…, K Jones, J Meier, H Olzscha, O Monteiro, S Martin… - Cancer research, 2015 - AACR
The histone acetyltransferases CBP/p300 are involved in recurrent leukemia-associated
chromosomal translocations and are key regulators of cell growth. Therefore, efforts to generate …
chromosomal translocations and are key regulators of cell growth. Therefore, efforts to generate …