The benefit of neuronavigation for neurosurgery analyzed by its impact on glioblastoma surgery

WS Rainer Wirtz, FK Albert, M Schwaderer… - Neurological …, 2000 - Taylor & Francis
Neuronavigation, today a routine method in neurosurgery, has not yet been systematically
assessed in direct comparison with conventional microsurgical techniques. The aim of the …

[HTML][HTML] Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo

R Gilsbach, M Schwaderer, S Preissl… - Nature …, 2018 - nature.com
Epigenetic mechanisms and transcription factor networks essential for differentiation of
cardiac myocytes have been uncovered. However, reshaping of the epigenome of these …

[HTML][HTML] DNA methylation signatures follow preformed chromatin compartments in cardiac myocytes

…, SA Doppler, S Preissl, M Schwaderer… - Nature …, 2017 - nature.com
Storage of chromatin in restricted nuclear space requires dense packing while ensuring
DNA accessibility. Thus, different layers of chromatin organization and epigenetic control …

Deciphering the epigenetic code of cardiac myocyte transcription

S Preissl, M Schwaderer, A Raulf, M Hesse… - Circulation …, 2015 - Am Heart Assoc
Rationale: Epigenetic mechanisms are crucial for cell identity and transcriptional control.
The heart consists of different cell types, including cardiac myocytes, endothelial cells, …

[HTML][HTML] Short-term safety results from compassionate use of risdiplam in patients with spinal muscular atrophy in Germany

…, M Weiler, K Neuland, MS Schwaderer… - Orphanet journal of rare …, 2022 - Springer
Background The oral, selective SMN2-splicing modifier risdiplam obtained European approval
in March 2021 for the treatment of patients ≥ 2 months old with a clinical diagnosis of 5q-…

The transcription factor ETV1 induces atrial remodeling and arrhythmia

…, S Roesner, A Lother, M Barg, M Schwaderer… - Circulation …, 2018 - Am Heart Assoc
Rationale: Structural and electrophysiological remodeling of the atria are recognized
consequences of sustained atrial arrhythmias, such as atrial fibrillation. The identification of …

[PDF][PDF] NEW METHODS

S Preissl, M Schwaderer, A Raulf, M Hesse… - bioinf.uni-freiburg.de
Rationale: Epigenetic mechanisms are crucial for cell identity and transcriptional control.
The heart consists of different cell types including cardiac myocytes, endothelial cells, …

In vivo silencing of regulatory elements using a single AAV-CRISPRi vector

…, C Cao, D Ramanujam, M Schwaderer… - Circulation …, 2024 - Am Heart Assoc
CRISPR-Cas9–based transcriptional repressors (CRISPRi) have emerged as powerful
tools for functional epigenetic silencing. 1 They rely on a nucleasedeficient Cas9 fused to a …

The role and molecular mechanism of epigenetics in cardiac hypertrophy

H Lei, J Hu, K Sun, D Xu - Heart failure reviews, 2021 - Springer
Cardiac hypertrophy is a significant risk factor for cardiovascular disease, including heart
failure, arrhythmia, and sudden death. Cardiac hypertrophy involves both embryonic gene …