Accurate pathological diagnosis is crucial for optimal management of patients with cancer.
For the approximately 100 known tumour types of the central nervous system, standardization …

Glioblastoma (GBM) is a brain tumor that carries a dismal prognosis and displays considerable
heterogeneity. We have recently identified recurrent H3F3A mutations affecting two …

Ependymal tumors across age groups are currently classified and graded solely by histopathology.
It is, however, commonly accepted that this classification scheme has limited clinical …

Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly
aggressive, poorly differentiated embryonal tumors occurring predominantly in young children …

Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and
children. They represent a morphologically heterogeneous class of tumours and some entities …

Background The WHO classification of brain tumours describes 15 subtypes of meningioma.
Nine of these subtypes are allotted to WHO grade I, and three each to grade II and grade III. …

Despite the histological similarity of ependymomas from throughout the neuroaxis, the
disease likely comprises multiple independent entities, each with a distinct molecular …

The large diversity of central nervous system (CNS) tumor types in children and adolescents
results in disparate patient outcomes and renders accurate diagnosis challenging. In this …

Infant high-grade gliomas in the cerebral hemispheres comprise novel subgroups, with a
prevalence of ALK, NTRK1/2/3, ROS1 , or MET gene fusions. Kinase fusion–positive tumors …

Recently, we described a machine learning approach for classification of central nervous
system tumors based on the analysis of genome-wide DNA methylation patterns [ 6 ]. Here, we …