Approaches exploiting trait distribution extremes may be used to identify loci associated
with common traits, but it is unknown whether these loci are generalizable to the broader …

Genome-wide association studies (GWAS) have identified more than 100 genetic variants
contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHR …

We performed fine mapping of 39 established type 2 diabetes (T2D) loci in 27,206 cases and
57,574 controls of European ancestry. We identified 49 distinct association signals at these …

We carried out a trans-ancestry genome-wide association and replication study of blood
pressure phenotypes among up to 320,251 individuals of East Asian, European and South …

Few genome-wide association studies (GWAS) account for environmental exposures, like
smoking, potentially impacting the overall trait variance when investigating the genetic …

Aims Risks of catheter ablation for atrial fibrillation and flutter assessed in retrospective studies,
registries, and controlled trials may underestimate ‘real world’ conditions. Methods and …

Genome-wide association studies have previously identified 23 genetic loci associated with
circulating fibrinogen concentration. These studies used HapMap imputation and did not …

To identify novel coding association signals and facilitate characterization of mechanisms
influencing glycemic traits and type 2 diabetes risk, we analyzed 109,215 variants derived …

Atrial fibrillation (AF) is a heritable disease that affects more than thirty million individuals
worldwide. Extensive efforts have been devoted to the study of genetic determinants of AF. The …

It has been hypothesized that low frequency (1–5% minor allele frequency (MAF)) and rare (<1%
MAF) variants with large effect sizes may contribute to the missing heritability in …