Asymmetry in the structure of the ABC transporter-binding protein complex BtuCD-BtuF

RN Hvorup, BA Goetz, M Niederer, K Hollenstein… - Science, 2007 - science.org
BtuCD is an adenosine triphosphate–binding cassette (ABC) transporter that translocates
vitamin B 12 from the periplasmic binding protein BtuF into the cytoplasm of Escherichia coli. …

Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins

…, J Kowal, EV Filippova, M Niederer… - Proceedings of the …, 2021 - National Acad Sciences
With conformation-specific nanobodies being used for a wide range of structural, biochemical,
and cell biological applications, there is a demand for antigen-binding fragments (Fabs) …

[HTML][HTML] Copper starvation-inducible protein for cytochrome oxidase biogenesis in Bradyrhizobium japonicum

…, HM Fischer, R Brogioli, M Niederer… - Journal of Biological …, 2012 - ASBMB
Microarray analysis of Bradyrhizobium japonicum grown under copper limitation uncovered
five genes named pcuABCDE, which are co-transcribed and co-regulated as an operon. The …

Structural and functional investigations of bacterial MFS-and MATE-type multidrug transporters

M Niederer - 2012 - research-collection.ethz.ch
Cells and organelles are surrounded by biological membranes that serve as selective
barriers. Import of nutrients and export of waste products across membranes are mediated by …

[PDF][PDF] Structural and functional characterization of the multidrug ABC transporter Sav1866 from Staphylococcus aureus

RJP Dawson - 2007 - research-collection.ethz.ch
ATP binding cassette (ABC) transporters are integral membrane proteins that actively transport
chemically diverse substrates across the lipid bilayers of cellular membranes. Clinically …

Impact of clinical risk scores and BRAF V600E mutation status on outcome in papillary thyroid cancer

SM Niederer-Wüst, W Jochum, D Förbs, M Brändle… - Surgery, 2015 - Elsevier
Background To evaluate the relationship between the BRAF V600E mutation and clinicopathologic
parameters and to assess the impact of the BRAF V600E mutation and established …

Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy

…, A De Martin, F Ronchi, K Van Der Borght, R Niederer… - Science, 2019 - science.org
Myocarditis can develop into inflammatory cardiomyopathy through chronic stimulation of
myosin heavy chain 6–specific T helper (T H )1 and T H 17 cells. However, mechanisms …

[HTML][HTML] Comprehensive Grading System for Experimental Autoimmune Uveitis in Mice

A Shome, OO Mugisho, RL Niederer, ID Rupenthal - Biomedicines, 2023 - mdpi.com
Experimental autoimmune uveitis (EAU) is the most commonly used animal model to study
the progression of chronic uveitis and to test various therapies to treat the disease. However, …

Validation of a smartphone-based measurement tool for the quantification of level walking

M Furrer, L Bichsel, M Niederer, H Baur, S Schmid - Gait & posture, 2015 - Elsevier
Introduction It is important to assess and quantify gait in order to determine the severity of
impairments during gait and to evaluate therapeutic interventions. However, laboratory gait …

Studies of conformational rearrangements during the transport cycle of bacterial ABC transporters

BA Götz - 2009 - research-collection.ethz.ch
… Cross-linking studies were also performed with mutants engineered in the periplasmic
surface of the TMDs (T276S and A281C) (done by Martina Niederer from our laboratory). In the …