Light-sheet fluorescence microscopy is a rapidly growing technique that has gained tremendous
popularity in the life sciences owing to its high-spatiotemporal resolution and gentle, …

Light-sheet microscopy is an ideal technique for imaging large cleared samples; however,
the community is still lacking instruments capable of producing volumetric images of …

Imaging large, cleared samples requires microscope objectives that combine a large field of
view (FOV) with a long working distance (WD) and a high numerical aperture (NA). Ideally, …

In 2015, we launched the mesoSPIM initiative, an open-source project for making light-sheet
microscopy of large cleared tissues more accessible. Meanwhile, the demand for imaging …

Intellectual disability (ID) is a neurodevelopmental disorder frequently caused by monogenic
defects. In this study, we collected 14 SEMA6B heterozygous variants in 16 unrelated …

Axon navigation depends on the interactions between guidance molecules along the trajectory
and specific receptors on the growth cone. However, our in vitro and in vivo studies on …

In 2015, we launched the mesoSPIM initiative (www.mesospim.org), an open-source project
aimed at making light-sheet microscopes for large cleared tissues more accessible. Since …

Axonal growth and guidance rely on correct growth cone responses to guidance cues.
Unlike the signaling cascades that link axonal growth to cytoskeletal dynamics, little is known …

The importance of cell adhesion molecules for the development of the nervous system has
been recognized many decades ago. Functional in vitro and in vivo studies demonstrated a …

Cell migration and axon guidance are important steps in the formation of neural circuits. Both
steps depend on the interactions between cell surface receptors and molecules on cells …