RNA-based therapeutics hold great promise for treating diseases and lipid nanoparticles (LNPs)
represent the most advanced platform for RNA delivery. However, the fate of the LNP-…

Aim Neutrophil extracellular traps (NETs) are mesh-like DNA fibers clad with intracellular
proteins that are cast out from neutrophils in response to certain stimuli. The process is thought …

Lipid nanoparticles (LNPs) are currently used to transport functional mRNAs, such as COVID‐19
mRNA vaccines. The delivery of angiogenic molecules, such as therapeutic VEGF‐A …

Background This study aimed to profile levels of blood cells and serum cytokines during
afebrile and febrile phases of periodic fever, aphthous stomatitis, pharyngitis and adenitis (…

Activation of professional phagocytes, potent microbial killers of our innate immune system,
is associated with an increase in cellular consumption of molecular oxygen (O 2 ). The …

CD38 is a multifunctional protein expressed on the surface of B cells in healthy individuals
but also in B cell malignancies. Previous studies have suggested a connection between …

Neutrophils, the most abundant white blood cell in human blood, express receptors that
recognize damage/microbial associated pattern molecules of importance for cell recruitment to …

Chronic granulomatous disease (CGD) is caused by mutations in genes that encode the
NADPH-oxidase and result in a failure of phagocytic cells to produce reactive oxygen species (…

Activation as well as recruitment of neutrophils, the most abundant leukocyte in human blood,
to sites of infection/inflammation largely rely on surface-exposed chemoattractant receptors…

G-protein coupled receptor (GPCR) biased agonism or functional selectivity has become an
essential concept in GPCR research over the last years. Receptor-specific biased agonists …