Surgical resection of tumours requires precisely locating and defining the margins between
lesions and normal tissue. However, this is made difficult by irregular margin borders. …

Inflammasomes are intracellular protein complexes that promote an inflammatory host
defense in response to pathogens and damaged or neoplastic tissues and are implicated in …

Molecularly targeted optical contrast agents have the potential to enable surgeons to visualize
specific molecular markers that can help improve surgical precision and thus outcomes. …

Clostridium difficile infection (CDI) is an enteric bacterial disease that is increasing in
prevalence worldwide. C. difficile capitalizes on gut inflammation and microbiome dysbiosis to …

Enzymatic inactivation of Rho-family GTPases by the glucosyltransferase domain of
Clostridioides difficile Toxin B (TcdB) gives rise to various pathogenic effects in cells that are …

Fluorescently quenched probes that are specifically activated in the cancer microenvironment
have great potential application for diagnosis, early detection, and surgical guidance. …

Otitis media (OM) or middle ear infection is one of the most common diseases in young
children around the world. The diagnosis of OM is currently performed using an otoscope to …

The cysteine protease cathepsin L (CTSL) is often thought to act as a tumor promoter by
enhancing tumor progression and metastasis. This goes along with increased CTSL activity in …

For a long time, lysosomes were purely seen as organelles in charge of garbage disposal
within the cell. They destroy any cargo delivered into their lumen with a plethora of highly …

The lysosomal protease cathepsin L has been reported to cleave various functionally important
cytosolic or nuclear proteins. To explain nucleo-cytosolic localization of cathepsin L, it …